Literature DB >> 11560317

Novel resorcin[4]arenes as potassium-selective ion-channel and transporter mimics.

A J Wright1, S E Matthews, W B Fischer, P D Beer.   

Abstract

A series of novel resorcin-[4]arenes with extended pi systems have been synthesised and developed as potassium-selective transporters. Resorcin[4]arenes that feature crown ether moieties function as efficient carriers of K+ across bulk liquid membranes showing enhanced selectivity over the other alkali metal ions relative to a model system (benzo[15]crown-5). Incorporation of functionalities suitable for pore formation, in addition to an extra annulus of aromatic residues, gives molecules which have remarkable ion-channel-mimicking behaviour in a biological lipid bilayer with outstanding K+/Na+ selectivity.

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Year:  2001        PMID： 11560317     DOI： 10.1002/1521-3765(20010817)7:16<3474::aid-chem3474>3.0.co;2-6

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  6 in total

1.  Calixarene-Mediated Liquid Membrane Transport of Choline Conjugates 2: Transport of Drug-Choline Conjugates and Neurotransmitters.

Authors:  Birendra Babu Adhikari; Sahar Roshandel; Ayu Fujii; Michael P Schramm
Journal:  European J Org Chem       Date:  2015-04-01

2.  Transmembrane pores formed by synthetic p-octiphenyl beta-barrels with internal carboxylate clusters: regulation of ion transport by pH and Mg(2+)- complexed 8-aminonaphthalene-1,3,6-trisulfonate.

Authors:  Gopal Das; Stefan Matile
Journal:  Proc Natl Acad Sci U S A       Date:  2002-03-12       Impact factor: 11.205

3.  Calixarene-mediated liquid membrane transport of choline conjugates 3: The effect of handle variation on neurotransmitter transport.

Authors:  James L Collins; Ayu Fujii; Sahar Roshandel; Cuong-Alexander To; Michael P Schramm
Journal:  Bioorg Med Chem Lett       Date:  2017-05-05       Impact factor: 2.823

4.  Biomimetic potassium-selective nanopores.

Authors:  Elif Turker Acar; Steven F Buchsbaum; Cody Combs; Francesco Fornasiero; Zuzanna S Siwy
Journal:  Sci Adv       Date:  2019-02-08       Impact factor: 14.136

5.  Novel octavalent cross-linker displays efficient trapping of protein-protein interactions.

Authors:  Simon R Foster; Alice Pearce; Alexander J Blake; Melanie J Welham; James Dowden
Journal:  Chem Commun (Camb)       Date:  2007-03-20       Impact factor: 6.222

6.  Ionic amplifying circuits inspired by electronics and biology.

Authors:  Rachel A Lucas; Chih-Yuan Lin; Lane A Baker; Zuzanna S Siwy
Journal:  Nat Commun       Date:  2020-03-26       Impact factor: 14.919
  6 in total

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