Literature DB >> 1156029

Electrophysiological evidence for an inhibitory action of diazepam upon cat brain cortex.

V V Zakusov, R U Ostrovskaya, V V Markovitch, G M Molodavkin, V M Bulayev.   

Abstract

Diazepam was shown to increase postexcitatory inhibition within the brain cortex as revealed by its influence upon the recovery cycles both of intracortical and primary responses. The specific interrelationship between diazepam and some drugs affecting brain GABA level suggests the possibility of a GABA mediated mechanism in the diazepam effect. The sensitivity of the brain cortex to diazepam is not lower than that of the amygdala and significantly higher than that of the hippocampus.

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Year:  1975        PMID: 1156029

Source DB:  PubMed          Journal:  Arch Int Pharmacodyn Ther        ISSN: 0003-9780


  7 in total

1.  Synaptic pharmacology of barbiturates and benzodiazepines.

Authors:  W E Haefely
Journal:  Agents Actions       Date:  1977-09

2.  Benzodiazepines and central inhibitory mechanisms.

Authors:  H M Geller; D A Taylor; B J Hoffer
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1978-09       Impact factor: 3.000

3.  Effects of diazepines and barbiturates on hippocampal recurrent inhibition.

Authors:  P Wolf; H L Haas
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-10       Impact factor: 3.000

4.  Effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus.

Authors:  P Polc; W Haefely
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1976-08       Impact factor: 3.000

5.  Effect of convulsant and anticonvulsant agents on level and metabolism of gamma-aminobutyric acid in mouse brain.

Authors:  W Löscher; H H Frey
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-02       Impact factor: 3.000

6.  Cortical inhibition processes and the anticonvulsant action of benzodiazepine derivatives.

Authors:  V V Markovich; R U Ostrovskaya
Journal:  Neurosci Behav Physiol       Date:  1980 May-Jun

7.  Phasic hippocampal activity during paradoxical sleep in the rat: selective suppression after diazepam administration.

Authors:  P Monmaur
Journal:  Experientia       Date:  1981-03-15
  7 in total

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