Studies on antibody response after implantation of Fibrin Bioplast preparations.

The authors implanted Fibrin Bioplast into the subcutaneous connective tissue, peritoneal cavity, and medullary cavity of tubular bones and into bone deficiencies produced by drilling of 22 rabbits, 38 guinea-pigs and 14 dogs. Immunodiffusion, passive haemagglutination and anaphylactic studies were performed and the delayed hypersensitivity reaction of the tuberculin type examined. Properly heat treated Fibrin Bioplast offered the least danger to the host organism.