Literature DB >> 11558492

Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimer's disease.

J C Lambert, D Mann, L Goumidi, J Harris, P Amouyel, T Iwatsubo, C Lendon, M C Chartier-Harlin.   

Abstract

Polymorphisms in the promoter region of the apolipoprotein E gene (APOE) affect the amount of amyloid peptide (Abeta) in the brains of patients with Alzheimer's disease. We measured Abeta load immunohistochemically in regions 8 and 9 of Brodman's area in 74 people with Alzheimer's disease. The amount of Abeta deposition was independent of APOE genotype in our cohort. These findings in patients with confirmed Alzheimer's disease are consistent with the hypothesis that variation in APOE expression directly affects Alzheimer's disease pathology.

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Year:  2001        PMID： 11558492     DOI： 10.1016/S0140-6736(00)04063-0

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  10 in total

1.  Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?

Authors:  J-C Lambert; D Mann; F Richard; J Tian; J Shi; U Thaker; S Merrot; J Harris; B Frigard; T Iwatsubo; C Lendon; P Amouyel
Journal:  J Neurol Neurosurg Psychiatry       Date:  2005-07       Impact factor: 10.154

Review 2.  Genetic influences on outcome following traumatic brain injury.

Authors:  Barry D Jordan
Journal:  Neurochem Res       Date:  2007-03-07       Impact factor: 3.996

3.  Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.

Authors:  Mónica Campillos; José Ramón Lamas; Miguel Angel García; María Jesús Bullido; Fernando Valdivieso; Jesús Vázquez
Journal:  Nucleic Acids Res       Date:  2003-06-15       Impact factor: 16.971

Review 4.  Intracellular cholesterol and phospholipid trafficking: comparable mechanisms in macrophages and neuronal cells.

Authors:  G Schmitz; E Orsó
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

5.  Association between Alzheimer disease and the -491T allele of regulatory region polymorphism of Apolipoprotein E in a Tunisian population.

Authors:  Afef Achouri-Rassas; Sondes Hadj Fredj; Hela Mrabet Khiari; Amina Bibi; Hajer Siala; Amel Mrabet; Taieb Messaoud
Journal:  Neurochem Res       Date:  2013-12-11       Impact factor: 3.996

6.  The complex interaction between APOE promoter and AD: an Italian case-control study.

Authors:  Alessandra Bizzarro; Davide Seripa; Adele Acciarri; Maria Giovanna Matera; Alberto Pilotto; Francesco Danilo Tiziano; Christina Brahe; Carlo Masullo
Journal:  Eur J Hum Genet       Date:  2009-01-28       Impact factor: 4.246

7.  The allelic modulation of apolipoprotein E expression by oestrogen: potential relevance for Alzheimer's disease.

Authors:  J-C Lambert; N Coyle; C Lendon
Journal:  J Med Genet       Date:  2004-02       Impact factor: 6.318

8.  Is there a significant interaction effect between apolipoprotein E rs405509 T/T and ε4 genotypes on cognitive impairment and gray matter volume?

Authors:  C Ma; Y Zhang; X Li; J Zhang; K Chen; Y Liang; Y Chen; Z Liu; Z Zhang
Journal:  Eur J Neurol       Date:  2016-06-04       Impact factor: 6.089

9.  Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol.

Authors:  Suzana S Petanceska; Steven DeRosa; Ali Sharma; Nichole Diaz; Karen Duff; Steven G Tint; Lorenzo M Refolo; Miguel Pappolla
Journal:  J Mol Neurosci       Date:  2003       Impact factor: 2.866

10.  Validating a Genomic Convergence and Network Analysis Approach Using Association Analysis of Identified Candidate Genes in Alzheimer's Disease.

Authors:  Puneet Talwar; Suman Kushwaha; Chitra Rawat; Harpreet Kaur; Ankit Srivastava; Rachna Agarwal; Puneet Chandna; Paolo Tucci; Luciano Saso; Ritushree Kukreti
Journal:  Front Genet       Date:  2021-12-09       Impact factor: 4.599
  10 in total

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