Literature DB >> 11557493

Effects of new quinolones on transepithelial electrical potential difference of tracheal mucosa in vivo.

S Kanoh1, J Tamaoki, M Kondo, Y Nagano, A Nagai.   

Abstract

Superfusion of canine tracheal mucosa with 100 microg each of grepafloxacin and ciprofloxacin per ml reduced the electrical transepithelial potential difference in vivo by more than 50%. This effect was dose dependent, specific for new quinolones, and inhibited by Cl channel blockers, indicating that new quinolones attenuate Cl secretion across the airway epithelium.

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Year:  2001        PMID： 11557493      PMCID： PMC90755          DOI： 10.1128/AAC.45.10.2928-2930.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Purification and reconstitution of an outwardly rectified Cl- channel from tracheal epithelia.

Authors:  B Jovov; V G Shlyonsky; B K Berdiev; I I Ismailov; D J Benos
Journal:  Am J Physiol       Date:  1998-08

Review 2.  Pharmacology of airway secretion.

Authors:  M G Marin
Journal:  Pharmacol Rev       Date:  1986-12       Impact factor: 25.468

Review 3.  Electrolyte transport by airway epithelia.

Authors:  M J Welsh
Journal:  Physiol Rev       Date:  1987-10       Impact factor: 37.312

4.  The comparative pharmacokinetics and tissue penetration of single-dose ciprofloxacin 400 mg i.v. and 750 mg po.

Authors:  C Catchpole; J M Andrews; J Woodcock; R Wise
Journal:  J Antimicrob Chemother       Date:  1994-01       Impact factor: 5.790

Review 5.  Human airway ion transport. Part one.

Authors:  R C Boucher
Journal:  Am J Respir Crit Care Med       Date:  1994-07       Impact factor: 21.405

Review 6.  Human airway ion transport. Part two.

Authors:  R C Boucher
Journal:  Am J Respir Crit Care Med       Date:  1994-08       Impact factor: 21.405

7.  Inhibition of acetylcholine-evoked Cl- currents by 14-membered macrolide antibiotics in isolated acinar cells of the guinea pig nasal gland.

Authors:  K Ikeda; D Wu; T Takasaka
Journal:  Am J Respir Cell Mol Biol       Date:  1995-10       Impact factor: 6.914

8.  Concentrations of OPC-17116, a new fluoroquinolone antibacterial, in serum and lung compartments.

Authors:  P J Cook; J M Andrews; R Wise; D Honeybourne; H Moudgil
Journal:  J Antimicrob Chemother       Date:  1995-02       Impact factor: 5.790

9.  Penetration of ciprofloxacin and metabolites into human lung, bronchial and pleural tissue after 250 and 500 mg oral ciprofloxacin.

Authors:  R Rohwedder; T Bergan; E Caruso; S B Thorsteinsson; H Della Torre; H Scholl
Journal:  Chemotherapy       Date:  1991       Impact factor: 2.544

Review 10.  Pharmacologic modulation of salt and water in the airway epithelium in cystic fibrosis.

Authors:  M R Knowles; K Olivier; P Noone; R C Boucher
Journal:  Am J Respir Crit Care Med       Date:  1995-03       Impact factor: 21.405
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  1 in total

Review 1.  Mechanisms of action and clinical application of macrolides as immunomodulatory medications.

Authors:  Soichiro Kanoh; Bruce K Rubin
Journal:  Clin Microbiol Rev       Date:  2010-07       Impact factor: 26.132
  1 in total

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