Literature DB >> 11557357

Functionalized amino acid anticonvulsants: synthesis and pharmacological evaluation of conformationally restricted analogues.

A LeTiran1, J P Stables, H Kohn.   

Abstract

Proven conformationally restricted analogues of anticonvulsant functionalized amino acids (FAAs) were prepared using short-range cyclizations and evaluated in pharmacological assays providing new information concerning the structural requirements for FAA function.

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Year:  2001        PMID： 11557357     DOI： 10.1016/s0968-0896(01)00204-8

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  7 in total

1.  Novel furanoid alpha-substitued alpha-amino acid as a potent turn mimic in peptide synthesis.

Authors:  Miroslava Martinková; Jozef Gonda; Jana Raschmanová
Journal:  Molecules       Date:  2006-07-26       Impact factor: 4.411

Review 2.  Lacosamide.

Authors:  Pamela Doty; G David Rudd; Thomas Stoehr; Dirk Thomas
Journal:  Neurotherapeutics       Date:  2007-01       Impact factor: 7.620

3.  Synthesis and anticonvulsant activities of N-benzyl (2R)-2-acetamido-3-oxysubstituted propionamide derivatives.

Authors:  Pierre Morieux; James P Stables; Harold Kohn
Journal:  Bioorg Med Chem       Date:  2008-08-28       Impact factor: 3.641

4.  Differential regulation of collapsin response mediator protein 2 (CRMP2) phosphorylation by GSK3ß and CDK5 following traumatic brain injury.

Authors:  Sarah M Wilson; Seul Ki Yeon; Xiao-Fang Yang; Ki Duk Park; Rajesh Khanna
Journal:  Front Cell Neurosci       Date:  2014-05-28       Impact factor: 5.505

5.  Lacosamide as treatment for partial epilepsy: mechanisms of action, pharmacology, effects, and safety.

Authors:  Christoph Kellinghaus
Journal:  Ther Clin Risk Manag       Date:  2009-09-24       Impact factor: 2.423

Review 6.  The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity.

Authors:  Martin Kalník; Peter Gabko; Maroš Bella; Miroslav Koóš
Journal:  Molecules       Date:  2021-06-30       Impact factor: 4.411

7.  The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.

Authors:  Sarah M Wilson; Aubin Moutal; Ohannes K Melemedjian; Yuying Wang; Weina Ju; Liberty François-Moutal; May Khanna; Rajesh Khanna
Journal:  Front Cell Neurosci       Date:  2014-07-24       Impact factor: 5.505
  7 in total

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