| Literature DB >> 11557352 |
R Kumar1, A Azim, V Kumar, S K Sharma, A K Prasad, O W Howarth, C E Olsen, S C Jain, V S Parmar.
Abstract
The chemo- and enantioselective capabilities of porcine pancreatic lipase (PPL) in tetrahydrofuran, and Candida rugosa lipase (CRL) in diisopropyl ether have been investigated for the acetylation of racemic 2-alkyl/aryl-3-hydroxypropiophenones, which are important precursors in the synthesis of biologically active chromanones and isoflavanones. A highly chemoselective acetylation of primary hydroxy group in preference to phenolic hydroxy group leading to the formation of enantiomerically enriched monoacetates has been observed.Entities:
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Year: 2001 PMID： 11557352 DOI： 10.1016/s0968-0896(01)00184-5
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641