Literature DB >> 11556022

Effect of saponin on mortality and histopathological changes in mice.

F H Diwan1, I A Abdel-Hassan, S T Mohammed.   

Abstract

We evaluated the acute toxicity and histopathological effects of saponin (extracted from the plant Citrullus colocynthis) on mice in order to assess its safety. The median lethal dose (LD50) of the saponin was 200 mg/kg. The histological changes were confined to the small intestine, liver and kidney, whereas the stomach, large intestine and heart appeared normal. The changes in the small intestine included haemorrhage and erosion of the mucosa. In addition, hepatorenal damage resulted from necrosis of liver cells and renal tubules.

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Year:  2000        PMID： 11556022

Source DB:  PubMed          Journal:  East Mediterr Health J        ISSN： 1020-3397            Impact factor:   1.628


  8 in total

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7.  Therapeutic effects of Citrullus colocynthis fruit in patients with type II diabetes: A clinical trial study.

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  8 in total

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