M Sbei1, J V Campellone. 1. Department of Neurology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Abstract
PURPOSE: To report that acute lamotrigine poisoning may result in severe encephalopathy. METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy. RESULTS: LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels. CONCLUSIONS: LTG overdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTG toxicity should be considered in patients taking this drug who have depressed mental status.
PURPOSE: To report that acute lamotriginepoisoning may result in severe encephalopathy. METHODS: A 55-year-old woman became stuporous after overdose with lamotrigine (LTG) and valproic acid (VPA) tablets. Evaluation revealed elevated serum LTG levels and no other etiology for encephalopathy. RESULTS:LTG was withheld, and the patient experienced a complete recovery in conjunction with reduced serum levels. CONCLUSIONS:LTGoverdose may result in a severe but reversible encephalopathy, a previously undescribed phenomenon. LTGtoxicity should be considered in patients taking this drug who have depressed mental status.