2'C-alkoxy and 2'-C-aryloxy derivatives of N-(2-phosphonomethoxyethyl)-purines and -pyrimidines: synthesis and biological activity.

A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship within the area of acyclic nucleotide analogues.