[Progress in study for mechanism of gastric mucosal injury].

Inflammatory reactions mediated by leukocytes, cytokines, adhesion molecules, active oxygen species, nitric oxide(NO) or prostaglandins have been implicated in the pathogenesis of gastric mucosal injury induced by Helicobacter pylori(H. pylori) or nonsteroidal anti-inflammatory drugs(NSAID). The molecular mechanism of gastric mucosal injury has been investigated in view of cell proliferation, apoptosis or necrosis. Eradication therapy of H. pylori, Cox2 inhibitors or NO-releasing NSAID may become new strategy for protection against gastric mucosal injury.