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Literature DB >> 11553715

The domain structure of centromeres is conserved from fission yeast to humans.

B Kniola¹, E O'Toole, J R McIntosh, B Mellone, R Allshire, S Mengarelli, K Hultenby, K Ekwall.

Abstract

The centromeric DNA of fission yeast is arranged with a central core flanked by repeated sequences. The centromere-associated proteins, Mis6p and Cnp1p (SpCENP-A), associate exclusively with central core DNA, whereas the Swi6 protein binds the surrounding repeats. Here, electron microscopy and immunofluorescence light microscopy reveal that the central core and flanking regions occupy distinct positions within a heterochromatic domain. An "anchor" structure containing the Ndc80 protein resides between this heterochromatic domain and the spindle pole body. The organization of centromere-associated proteins in fission yeast is reminiscent of the multilayered structures of human kinetochores, indicating that such domain structure is conserved in eukaryotes.

Entities: Gene Species

Mesh：

Substances：

Year: 2001 PMID： 11553715 PMCID： PMC59711 DOI： 10.1091/mbc.12.9.2767

Source DB: PubMed Journal: Mol Biol Cell ISSN： 1059-1524 Impact factor: 4.138

43 in total

1. Proper metaphase spindle length is determined by centromere proteins Mis12 and Mis6 required for faithful chromosome segregation.

Authors: G Goshima; S Saitoh; M Yanagida
Journal: Genes Dev Date: 1999-07-01 Impact factor: 11.361

2. Requirement of Mis6 centromere connector for localizing a CENP-A-like protein in fission yeast.

Authors: K Takahashi; E S Chen; M Yanagida
Journal: Science Date: 2000-06-23 Impact factor: 47.728

Review 3. Centromeres: getting a grip of chromosomes.

Authors: A L Pidoux; R C Allshire
Journal: Curr Opin Cell Biol Date: 2000-06 Impact factor: 8.382

4. Fission yeast mutants that alleviate transcriptional silencing in centromeric flanking repeats and disrupt chromosome segregation.

Authors: K Ekwall; G Cranston; R C Allshire
Journal: Genetics Date: 1999-11 Impact factor: 4.562

5. Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31.

Authors: L Aagaard; G Laible; P Selenko; M Schmid; R Dorn; G Schotta; S Kuhfittig; A Wolf; A Lebersorger; P B Singh; G Reuter; T Jenuwein
Journal: EMBO J Date: 1999-04-01 Impact factor: 11.598

6. Distinct protein interaction domains and protein spreading in a complex centromere.

Authors: J F Partridge; B Borgstrøm; R C Allshire
Journal: Genes Dev Date: 2000-04-01 Impact factor: 11.361

7. The fission yeast chromo domain encoding gene chp1(+) is required for chromosome segregation and shows a genetic interaction with alpha-tubulin.

Authors: C L Doe; G Wang; C Chow; M D Fricker; P B Singh; E J Mellor
Journal: Nucleic Acids Res Date: 1998-09-15 Impact factor: 16.971

8. Live analysis of lagging chromosomes during anaphase and their effect on spindle elongation rate in fission yeast.

Authors: A L Pidoux; S Uzawa; P E Perry; W Z Cande; R C Allshire
Journal: J Cell Sci Date: 2000-12 Impact factor: 5.285

9. Slk19p is a centromere protein that functions to stabilize mitotic spindles.

Authors: X Zeng; J A Kahana; P A Silver; M K Morphew; J R McIntosh; I T Fitch; J Carbon; W S Saunders
Journal: J Cell Biol Date: 1999-07-26 Impact factor: 10.539

10. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry.

Authors: P A Wigge; O N Jensen; S Holmes; S Souès; M Mann; J V Kilmartin
Journal: J Cell Biol Date: 1998-05-18 Impact factor: 10.539

41 in total

1. Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+.

Authors: Satoru Uzawa; Fei Li; Ye Jin; Kent L McDonald; Michael B Braunfeld; David A Agard; W Zacheus Cande
Journal: Mol Biol Cell Date: 2004-09-22 Impact factor: 4.138

2. The Clr7 and Clr8 directionality factors and the Pcu4 cullin mediate heterochromatin formation in the fission yeast Schizosaccharomyces pombe.

Authors: Geneviève Thon; Klavs R Hansen; Susagna Padrissa Altes; Deepak Sidhu; Gurjeet Singh; Janne Verhein-Hansen; Michael J Bonaduce; Amar J S Klar
Journal: Genetics Date: 2005-09-12 Impact factor: 4.562

3. Centromere positioning and dynamics in living Arabidopsis plants.

Authors: Yuda Fang; David L Spector
Journal: Mol Biol Cell Date: 2005-09-29 Impact factor: 4.138

Review 4. The role of heterochromatin in centromere function.

Authors: Alison L Pidoux; Robin C Allshire
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2005-03-29 Impact factor: 6.237

5. The mal2p protein is an essential component of the fission yeast centromere.

Authors: Quan-Wen Jin; Alison L Pidoux; Corina Decker; Robin C Allshire; Ursula Fleig
Journal: Mol Cell Biol Date: 2002-10 Impact factor: 4.272

Review 6. The composition, functions, and regulation of the budding yeast kinetochore.

Authors: Sue Biggins
Journal: Genetics Date: 2013-08 Impact factor: 4.562

7. RNA interference (RNAi)-dependent and RNAi-independent association of the Chp1 chromodomain protein with distinct heterochromatic loci in fission yeast.

Authors: Victoria J Petrie; Jeffrey D Wuitschick; Cheryl D Givens; Aaron M Kosinski; Janet F Partridge
Journal: Mol Cell Biol Date: 2005-03 Impact factor: 4.272