Literature DB >> 11553607

DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection.

L Planelles1, M C Thomas, C Alonso, M C López.   

Abstract

Murine immunization with Trypanosoma cruzi KMP11-HSP70 fused genes but not the KMP11 gene alone elicited both an immunoglobulin G2a long-lasting humoral immune response against KMP11 protein and activation of CD8+ cytotoxic T lymphocytes specific for two KMP11 peptides containing A2 motifs. Moreover, protection against the parasite challenge was observed after immunization with the chimeric gene.

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Year:  2001        PMID： 11553607      PMCID： PMC98798          DOI： 10.1128/IAI.69.10.6558-6563.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  31 in total

1.  Mapping of the antigenic determinants of the T. cruzi kinetoplastid membrane protein-11. Identification of a linear epitope specifically recognized by human Chagasic sera.

Authors:  M C Thomas; M V Longobardo; E Carmelo; C Marañón; L Planelles; M E Patarroyo; C Alonso; M C López
Journal:  Clin Exp Immunol       Date:  2001-03       Impact factor: 4.330

2.  HSP70 from Trypanosoma cruzi is endowed with specific cell proliferation potential leading to apoptosis.

Authors:  C Marañón; L Planelles; C Alonso; M C López
Journal:  Int Immunol       Date:  2000-12       Impact factor: 4.823

3.  Vaccination with trypomastigote surface antigen 1-encoding plasmid DNA confers protection against lethal Trypanosoma cruzi infection.

Authors:  B Wizel; N Garg; R L Tarleton
Journal:  Infect Immun       Date:  1998-11       Impact factor: 3.441

4.  CD91: a receptor for heat shock protein gp96.

Authors:  R J Binder; D K Han; P K Srivastava
Journal:  Nat Immunol       Date:  2000-08       Impact factor: 25.606

5.  Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes.

Authors:  Y H Chow; B L Chiang; Y L Lee; W K Chi; W C Lin; Y T Chen; M H Tao
Journal:  J Immunol       Date:  1998-02-01       Impact factor: 5.422

6.  Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway.

Authors:  K Suzue; X Zhou; H N Eisen; R A Young
Journal:  Proc Natl Acad Sci U S A       Date:  1997-11-25       Impact factor: 11.205

7.  Molecular characterization of KMP11 from Trypanosoma cruzi: a cytoskeleton-associated protein regulated at the translational level.

Authors:  M C Thomas; J L García-Pérez; C Alonso; M C López
Journal:  DNA Cell Biol       Date:  2000-01       Impact factor: 3.311

8.  Modulation of the immune response to DNA vaccine by co-delivery of costimulatory molecules.

Authors:  J Fló; S Tisminetzky; F Baralle
Journal:  Immunology       Date:  2000-06       Impact factor: 7.397

9.  Cross-priming of CTL responses in vivo does not require antigenic peptides in the endoplasmic reticulum of immunizing cells.

Authors:  S P Schoenberger; E I van der Voort; G M Krietemeijer; R Offringa; C J Melief; R E Toes
Journal:  J Immunol       Date:  1998-10-15       Impact factor: 5.422

10.  In vivo cytotoxic T lymphocyte elicitation by mycobacterial heat shock protein 70 fusion proteins maps to a discrete domain and is CD4(+) T cell independent.

Authors:  Q Huang; J F Richmond; K Suzue; H N Eisen; R A Young
Journal:  J Exp Med       Date:  2000-01-17       Impact factor: 14.307
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  23 in total

1.  CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2.

Authors:  Adriano F S Araújo; Bruna C G de Alencar; José Ronnie C Vasconcelos; Meire I Hiyane; Cláudio R F Marinho; Marcus L O Penido; Silvia B Boscardin; Daniel F Hoft; Ricardo T Gazzinelli; Mauricio M Rodrigues
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

2.  Molecular cloning and characterization of a cytosolic heat shock protein 70 from Naegleria fowleri.

Authors:  Kyoung-Ju Song; Kyung-Hui Song; Byoung-Kuk Na; Jong-Hyun Kim; Daeho Kwon; Sun Park; Jhang-Ho Pak; Kyung-Il Im; Ho-Joon Shin
Journal:  Parasitol Res       Date:  2007-01-25       Impact factor: 2.289

3.  Th1 stimulatory proteins of Leishmania donovani: comparative cellular and protective responses of rTriose phosphate isomerase, rProtein disulfide isomerase and rElongation factor-2 in combination with rHSP70 against visceral leishmaniasis.

Authors:  Anil Kumar Jaiswal; Prashant Khare; Sumit Joshi; Pramod Kumar Kushawaha; Shyam Sundar; Anuradha Dube
Journal:  PLoS One       Date:  2014-09-30       Impact factor: 3.240

4.  Immunization with cDNA expressed by amastigotes of Trypanosoma cruzi elicits protective immune response against experimental infection.

Authors:  Silvia B Boscardin; Sheila S Kinoshita; Adriana E Fujimura; Mauricio M Rodrigues
Journal:  Infect Immun       Date:  2003-05       Impact factor: 3.441

5.  Utility of the Trypanosoma cruzi sequence database for identification of potential vaccine candidates by in silico and in vitro screening.

Authors:  Vandanajay Bhatia; Mala Sinha; Bruce Luxon; Nisha Garg
Journal:  Infect Immun       Date:  2004-11       Impact factor: 3.441

6.  Immunotherapy of Trypanosoma cruzi infection with DNA vaccines in mice.

Authors:  Eric Dumonteil; Javier Escobedo-Ortegon; Norma Reyes-Rodriguez; Arletty Arjona-Torres; Maria Jesus Ramirez-Sierra
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

7.  Genetic immunization elicits antigen-specific protective immune responses and decreases disease severity in Trypanosoma cruzi infection.

Authors:  Nisha Garg; Rick L Tarleton
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

8.  Prophylactic efficacy of TcVac2 against Trypanosoma cruzi in mice.

Authors:  Shivali Gupta; Nisha Jain Garg
Journal:  PLoS Negl Trop Dis       Date:  2010-08-10

9.  Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas' disease.

Authors:  Eduardo L V Silveira; Carla Claser; Filipe A B Haolla; Luiz G Zanella; Mauricio M Rodrigues
Journal:  Clin Vaccine Immunol       Date:  2008-06-25

10.  Mucosal adjuvanticity of a Shigella invasin complex with dna-based vaccines.

Authors:  Robert W Kaminski; K Ross Turbyfill; C Chao; W M Ching; Edwin V Oaks
Journal:  Clin Vaccine Immunol       Date:  2009-02-18
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