Literature DB >> 11553596

Epitope mapping of neutralizing botulinum neurotoxin A antibodies by phage display.

B P Mullaney1, M G Pallavicini, J D Marks.   

Abstract

Single-chain antibodies neutralize activity and bind nonoverlapping epitopes of botulinum A neurotoxin. Two phage display epitope libraries were constructed from the 1.3 kb of binding domain cDNA. The minimal epitopes selected against the single-chain Fv-Fc antibodies correspond to conformational epitopes with amino acid residues 1115 to 1223 (S25), 1131 to 1264 (3D12), and 889 to 1294 (C25).

Entities:  

Mesh：

Substances：

Year:  2001        PMID： 11553596      PMCID： PMC98787          DOI： 10.1128/IAI.69.10.6511-6514.2001

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  25 in total

1.  Expression of single-chain Fv-Fc fusions in Pichia pastoris.

Authors:  D B Powers; P Amersdorfer; M Poul; U B Nielsen; M R Shalaby; G P Adams; L M Weiner; J D Marks
Journal:  J Immunol Methods       Date:  2001-05-01       Impact factor: 2.303

2.  Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B.

Authors:  S Swaminathan; S Eswaramoorthy
Journal:  Nat Struct Biol       Date:  2000-08

3.  Hepatitis C epitopes from phage-displayed cDNA libraries and improved diagnosis with a chimeric antigen.

Authors:  L A Pereboeva; A V Pereboev; L F Wang; G E Morris
Journal:  J Med Virol       Date:  2000-02       Impact factor: 2.327

4.  Multi-subunit proteins on the surface of filamentous phage: methodologies for displaying antibody (Fab) heavy and light chains.

Authors:  H R Hoogenboom; A D Griffiths; K S Johnson; D J Chiswell; P Hudson; G Winter
Journal:  Nucleic Acids Res       Date:  1991-08-11       Impact factor: 16.971

5.  Use of a gene-targeted phage display random epitope library to map an antigenic determinant on the bluetongue virus outer capsid protein VP5.

Authors:  L F Wang; D H Du Plessis; J R White; A D Hyatt; B T Eaton
Journal:  J Immunol Methods       Date:  1995-01-13       Impact factor: 2.303

6.  Mapping of the minimal domain encoding a conformational epitope by lambda phage surface display: factor VIII inhibitor antibodies from haemophilia A patients.

Authors:  I Kuwabara; H Maruyama; S Kamisue; M Shima; A Yoshioka; I N Maruyama
Journal:  J Immunol Methods       Date:  1999-04-22       Impact factor: 2.303

7.  Inhibition of tetanus toxin fragment C binding to ganglioside G(T1b) by monoclonal antibodies recognizing different epitopes.

Authors:  S P Fitzsimmons; K C Clark; R Wilkerson; M A Shapiro
Journal:  Vaccine       Date:  2000-08-15       Impact factor: 3.641

8.  Equine antitoxin use and other factors that predict outcome in type A foodborne botulism.

Authors:  C O Tacket; W X Shandera; J M Mann; N T Hargrett; P A Blake
Journal:  Am J Med       Date:  1984-05       Impact factor: 4.965

9.  Covalent structure of botulinum neurotoxin type A: location of sulfhydryl groups, and disulfide bridges and identification of C-termini of light and heavy chains.

Authors:  K G Krieglstein; B R DasGupta; A H Henschen
Journal:  J Protein Chem       Date:  1994-01

10.  Protective vaccination with a recombinant fragment of Clostridium botulinum neurotoxin serotype A expressed from a synthetic gene in Escherichia coli.

Authors:  M A Clayton; J M Clayton; D R Brown; J L Middlebrook
Journal:  Infect Immun       Date:  1995-07       Impact factor: 3.441
View more
  18 in total

1.  Genetic diversity among Botulinum Neurotoxin-producing clostridial strains.

Authors:  K K Hill; T J Smith; C H Helma; L O Ticknor; B T Foley; R T Svensson; J L Brown; E A Johnson; L A Smith; R T Okinaka; P J Jackson; J D Marks
Journal:  J Bacteriol       Date:  2006-11-17       Impact factor: 3.490

2.  Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization.

Authors:  T J Smith; J Lou; I N Geren; C M Forsyth; R Tsai; S L Laporte; W H Tepp; M Bradshaw; E A Johnson; L A Smith; J D Marks
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

Review 3.  High throughput functional epitope mapping: revisiting phage display platform to scan target antigen surface.

Authors:  Gertrudis Rojas; Yaima Tundidor; Yanelys Cabrera Infante
Journal:  MAbs       Date:  2014       Impact factor: 5.857

Review 4.  Immunity to ricin: fundamental insights into toxin-antibody interactions.

Authors:  Joanne M O'Hara; Anastasiya Yermakova; Nicholas J Mantis
Journal:  Curr Top Microbiol Immunol       Date:  2012       Impact factor: 4.291

5.  Fine and domain-level epitope mapping of botulinum neurotoxin type A neutralizing antibodies by yeast surface display.

Authors:  R Levy; C M Forsyth; S L LaPorte; I N Geren; L A Smith; J D Marks
Journal:  J Mol Biol       Date:  2006-10-03       Impact factor: 5.469

6.  Synergistic capture of Clostridium botulinum type A neurotoxin by scFv antibodies to novel epitopes.

Authors:  Sean A Gray; John R Barr; Suzanne R Kalb; James D Marks; Cheryl L Baird; Gerard A Cangelosi; Keith D Miller; Michael J Feldhaus
Journal:  Biotechnol Bioeng       Date:  2011-05-12       Impact factor: 4.530

7.  Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.

Authors:  Jasmin Strotmeier; Stefan Mahrhold; Nadja Krez; Constantin Janzen; Jianlong Lou; James D Marks; Thomas Binz; Andreas Rummel
Journal:  FEBS Lett       Date:  2014-02-25       Impact factor: 4.124

8.  Potent neutralization of botulinum neurotoxin by recombinant oligoclonal antibody.

Authors:  A Nowakowski; C Wang; D B Powers; P Amersdorfer; T J Smith; V A Montgomery; R Sheridan; R Blake; L A Smith; J D Marks
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-12       Impact factor: 11.205

9.  Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodies.

Authors:  Marvin G Warner; Jay W Grate; Abby Tyler; Richard M Ozanich; Keith D Miller; Jianlong Lou; James D Marks; Cynthia J Bruckner-Lea
Journal:  Biosens Bioelectron       Date:  2009-06-26       Impact factor: 10.618

10.  Epitope mapping of botulinum neurotoxins light chains.

Authors:  Alexey Zdanovsky; Denis Zdanovsky; Maria Zdanovskaia
Journal:  Toxicon       Date:  2012-08-14       Impact factor: 3.033
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.