BACKGROUND: Enteric infection by Giardia intestinalis is a common cause of diarrhoea world-wide and a significant cause of morbidity in children. AIM: To compare the efficacy and safety of nitazoxanide and metronidazole in the treatment of diarrhoea caused by G. intestinalis in children. METHODS: A total of 110 children presenting with diarrhoea caused by G. intestinalis were randomized to treatment with either a 3-day course of nitazoxanide (100 mg b.d., age range 2-3 years; 200 mg b.d., age range 4-11 years) or a 5-day course of metronidazole (125 mg b.d., age range 2-5 years; 250 mg b.d., age range 6-11 years). The patients were followed-up for a determination of clinical response 7 days after the initiation of treatment, and two subsequent stool samples were collected for parasitological examination. RESULTS:Diarrhoea had resolved in 47 children out of 55 (85%) in the nitazoxanide treatment group before the day 7 follow-up visit, compared to 44 out of 55 (80%) for metronidazole. Diarrhoea resolved within 4 days in most cases. Only mild, transient adverse events were reported. CONCLUSIONS: A 3-day course of nitazoxanide suspension is as efficacious as a standard 5-day course of metronidazole suspension in treating giardiasis in children.
RCT Entities:
BACKGROUND: Enteric infection by Giardia intestinalis is a common cause of diarrhoea world-wide and a significant cause of morbidity in children. AIM: To compare the efficacy and safety of nitazoxanide and metronidazole in the treatment of diarrhoea caused by G. intestinalis in children. METHODS: A total of 110 children presenting with diarrhoea caused by G. intestinalis were randomized to treatment with either a 3-day course of nitazoxanide (100 mg b.d., age range 2-3 years; 200 mg b.d., age range 4-11 years) or a 5-day course of metronidazole (125 mg b.d., age range 2-5 years; 250 mg b.d., age range 6-11 years). The patients were followed-up for a determination of clinical response 7 days after the initiation of treatment, and two subsequent stool samples were collected for parasitological examination. RESULTS:Diarrhoea had resolved in 47 children out of 55 (85%) in the nitazoxanide treatment group before the day 7 follow-up visit, compared to 44 out of 55 (80%) for metronidazole. Diarrhoea resolved within 4 days in most cases. Only mild, transient adverse events were reported. CONCLUSIONS: A 3-day course of nitazoxanide suspension is as efficacious as a standard 5-day course of metronidazole suspension in treating giardiasis in children.
Authors: Ana E Gamiño-Arroyo; M Lourdes Guerrero; Sean McCarthy; Alejandra Ramírez-Venegas; Beatriz Llamosas-Gallardo; Arturo Galindo-Fraga; Sarbelio Moreno-Espinosa; Yuri Roldán-Aragón; Javier Araujo-Meléndez; Sally Hunsberger; Violeta Ibarra-González; Julia Martínez-López; Luis A García-Andrade; Heather Kapushoc; H Preston Holley; Mary C Smolskis; Guillermo M Ruiz-Palacios; John H Beigel Journal: Clin Infect Dis Date: 2019-11-13 Impact factor: 9.079
Authors: Eloy G Moreno-Galindo; Julio C Rodríguez-Elías; Mario A Ramírez-Herrera; José A Sánchez-Chapula; Ricardo A Navarro-Polanco Journal: Pflugers Arch Date: 2013-09-17 Impact factor: 3.657
Authors: Yvonne Guttner; Helen M Windsor; Charlie H Viiala; Leon Dusci; Barry J Marshall Journal: Antimicrob Agents Chemother Date: 2003-12 Impact factor: 5.191