OBJECTIVES: We investigated the effects of alcohol consumption on the risk of cancers of the upper aerodigestive tract (UADT) in a hospital-based case-control study in Brazil. METHODS: A total of 784 cases of cancers of the mouth, pharynx, and larynx and 1578 non-cancer controls matched on age, gender, hospital area, and admission period provided information on alcohol drinking, smoking, and other characteristics via interview. Using logistic regression, we evaluated the relative risks (RR) of UADT cancer for different beverage types based on cumulative ethanol content exposure and frequency of consumption. RESULTS: Relative to nondrinkers of any alcohol, risks of UADT cancers varied across sites both with increased exposure to ethanol and by alcohol type. RRs at equivalent levels of ethanol consumption were highest for cancers of the mouth for hard liquor (6.9 for > 100 kg lifetime consumption, 95% confidence interval (CI) = 2.8-17.1) and cachaça (4.5 for 101-500 kg, 95% CI = 2.2-9.0). Although RRs increased with frequency of drinks per week, when evaluated against higher proportional alcohol intake, reductions in risk were observed for beer and wine. CONCLUSION: Although methods of measurement can influence the interpretation of the carcinogenic nature of alcohols, increased RRs persisted with continued exposure for all types.
OBJECTIVES: We investigated the effects of alcohol consumption on the risk of cancers of the upper aerodigestive tract (UADT) in a hospital-based case-control study in Brazil. METHODS: A total of 784 cases of cancers of the mouth, pharynx, and larynx and 1578 non-cancer controls matched on age, gender, hospital area, and admission period provided information on alcohol drinking, smoking, and other characteristics via interview. Using logistic regression, we evaluated the relative risks (RR) of UADT cancer for different beverage types based on cumulative ethanol content exposure and frequency of consumption. RESULTS: Relative to nondrinkers of any alcohol, risks of UADT cancers varied across sites both with increased exposure to ethanol and by alcohol type. RRs at equivalent levels of ethanol consumption were highest for cancers of the mouth for hard liquor (6.9 for > 100 kg lifetime consumption, 95% confidence interval (CI) = 2.8-17.1) and cachaça (4.5 for 101-500 kg, 95% CI = 2.2-9.0). Although RRs increased with frequency of drinks per week, when evaluated against higher proportional alcohol intake, reductions in risk were observed for beer and wine. CONCLUSION: Although methods of measurement can influence the interpretation of the carcinogenic nature of alcohols, increased RRs persisted with continued exposure for all types.
Authors: Mark P Purdue; Mia Hashibe; Julien Berthiller; Carlo La Vecchia; Luigino Dal Maso; Rolando Herrero; Silvia Franceschi; Xavier Castellsague; Qingyi Wei; Erich M Sturgis; Hal Morgenstern; Zuo-Feng Zhang; Fabio Levi; Renato Talamini; Elaine Smith; Joshua Muscat; Philip Lazarus; Stephen M Schwartz; Chu Chen; Jose Eluf Neto; Victor Wünsch-Filho; David Zaridze; Sergio Koifman; Maria Paula Curado; Simone Benhamou; Elena Matos; Neonilia Szeszenia-Dabrowska; Andrew F Olshan; Juan Lence; Ana Menezes; Alexander W Daudt; Ioan Nicolae Mates; Agnieszka Pilarska; Eleonora Fabianova; Peter Rudnai; Debbie Winn; Gilles Ferro; Paul Brennan; Paolo Boffetta; Richard B Hayes Journal: Am J Epidemiol Date: 2008-12-08 Impact factor: 4.897
Authors: Binh Y Goldstein; Shen-Chih Chang; Mia Hashibe; Carlo La Vecchia; Zuo-Feng Zhang Journal: Eur J Cancer Prev Date: 2010-11 Impact factor: 2.497
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Authors: Dirk W Lachenmeier; Maria C P Lima; Ian C C Nóbrega; José A P Pereira; Florence Kerr-Corrêa; Fotis Kanteres; Jürgen Rehm Journal: BMC Cancer Date: 2010-06-08 Impact factor: 4.430
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