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Literature DB >> 1155220

Plasma renin activity, blood pressure and sodium excretion during treatment with clonidine.

Abstract

Clonidine, 225 mug a day, has been given orally for 3 months to 15 patients with essential hypertension. Mean BP was reduced from 159/107 to 143/87 mmHg. The antihypertensive effect of the drug was dissociated from changes in plasma renin activity (PRA) during clonidine treatment. PRA levels decreased initially in 6 patients with the highest PRA values before treatment, but then increased again. In 6 patients with lower pretreatment PRA levels, PRA rose continuously. Opposite patterns of 24-hour urinary sodium excretion were observed in these arbitrary subgroups. The antihypertensive effect of clonidine in essential hypertension appears to be independent of changes in PRA.

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Year: 1975 PMID： 1155220 DOI： 10.1111/j.0954-6820.1975.tb04951.x

Source DB: PubMed Journal: Acta Med Scand ISSN： 0001-6101

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Cited

7 in total

7. Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans.

Authors: E R Samuels; E Szabadi
Journal: Curr Neuropharmacol Date: 2008-09 Impact factor: 7.363

7 in total

Plasma renin activity, blood pressure and sodium excretion during treatment with clonidine.

1. [Behaviour of plasma renin activity during long-term treatment with propranolol (author's transl)].

2. Effect of baroreflex activation therapy on renal sodium excretion in patients with resistant hypertension.

3. Treatment of hypertension successively with a diuretic, clonidine or a beta-blocking agent and hydralazine.

Review 4. Effect of antihypertensive drugs on the renin-angiotensin system.

5. Clonidine withdrawal. Mechanism and frequency of rebound hypertension.

6. Effect of guanfacine on blood pressure and renin activity in hypertensive patients.

7. Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part II: physiological and pharmacological manipulations and pathological alterations of locus coeruleus activity in humans.