Literature DB >> 11552037

Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients.

F Jessen1, W Block, F Träber, E Keller, S Flacke, R Lamerichs, H H Schild, R Heun.   

Abstract

In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.

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Year:  2001        PMID： 11552037     DOI： 10.1212/wnl.57.5.930

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


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