Literature DB >> 11551811

CO(2)/HCO(3)(-)-responsive soluble adenylyl cyclase as a putative metabolic sensor.

J H Zippin1, L R Levin, J Buck.   

Abstract

Cyclic AMP (cAMP) is an evolutionarily conserved regulator of metabolism. Recently, we identified a novel mammalian source of cAMP - soluble adenylyl cyclase (sAC) - that is regulated directly by bicarbonate ions (HCO(3)(-)). As the concentration of HCO(3)(-) reflects cellular levels of carbon dioxide (CO(2)), energy-generating metabolic processes (which increase intracellular CO(2)) are poised to activate bicarbonate-responsive sAC. This direct link between metabolic activity, sAC and cAMP could represent an evolutionarily conserved mechanism of metabolic feedback regulation.

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Year:  2001        PMID： 11551811     DOI： 10.1016/s1043-2760(01)00454-4

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  53 in total

1.  Bicarbonate-regulated adenylyl cyclase (sAC) is a sensor that regulates pH-dependent V-ATPase recycling.

Authors:  Nuria Pastor-Soler; Valerie Beaulieu; Tatiana N Litvin; Nicolas Da Silva; Yanqiu Chen; Dennis Brown; Jochen Buck; Lonny R Levin; Sylvie Breton
Journal:  J Biol Chem       Date:  2003-09-25       Impact factor: 5.157

Review 2.  Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling.

Authors:  Carl Nathan
Journal:  J Clin Invest       Date:  2003-03       Impact factor: 14.808

Review 3.  Role of soluble adenylyl cyclase in the heart.

Authors:  Jonathan Chen; Lonny R Levin; Jochen Buck
Journal:  Am J Physiol Heart Circ Physiol       Date:  2011-11-04       Impact factor: 4.733

4.  Sensing of inorganic carbon limitation in Synechococcus PCC7942 is correlated with the size of the internal inorganic carbon pool and involves oxygen.

Authors:  Fiona J Woodger; Murray R Badger; G Dean Price
Journal:  Plant Physiol       Date:  2005-11-23       Impact factor: 8.340

Review 5.  Molecular details of cAMP generation in mammalian cells: a tale of two systems.

Authors:  Margarita Kamenetsky; Sabine Middelhaufe; Erin M Bank; Lonny R Levin; Jochen Buck; Clemens Steegborn
Journal:  J Mol Biol       Date:  2006-07-28       Impact factor: 5.469

6.  Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment.

Authors:  Clemens Steegborn; Tatiana N Litvin; Lonny R Levin; Jochen Buck; Hao Wu
Journal:  Nat Struct Mol Biol       Date:  2004-12-26       Impact factor: 15.369

Review 7.  Control of outflow resistance by soluble adenylyl cyclase.

Authors:  Yong Suk Lee; Alan D Marmorstein
Journal:  J Ocul Pharmacol Ther       Date:  2013-12-09       Impact factor: 2.671

8.  Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.

Authors:  Mohammad Shahidullah; Amritlal Mandal; Guojun Wei; Lonny R Levin; Jochen Buck; Nicholas A Delamere
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-01-09       Impact factor: 4.799

9.  Pharmacological distinction between soluble and transmembrane adenylyl cyclases.

Authors:  Jacob L Bitterman; Lavoisier Ramos-Espiritu; Ana Diaz; Lonny R Levin; Jochen Buck
Journal:  J Pharmacol Exp Ther       Date:  2013-10-03       Impact factor: 4.030

10.  cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells.

Authors:  Teodor G Păunescu; Marija Ljubojevic; Leileata M Russo; Christian Winter; Margaret M McLaughlin; Carsten A Wagner; Sylvie Breton; Dennis Brown
Journal:  Am J Physiol Renal Physiol       Date:  2010-01-06
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