| Literature DB >> 11551768 |
M A Lynch1, O Duval, A Sukhanova, J Devy, S P MacKay, R D Waigh, I Nabiev.
Abstract
New antitumor 12-alkoxy-benzo[c]phenanthridinium derivatives were obtained in high yields through multistep syntheses. Analysis of DNA binding and human DNA topoisomerase I inhibitory activities demonstrates that new compounds, combining 2, 6, and 12 substitutions, interact strongly with DNA and exhibit important topoisomerase I inhibition. The cytotoxicities against solid tumor cell lines are also determined and compared with those for fagaronine and ethoxidine.Entities:
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Year: 2001 PMID： 11551768 DOI： 10.1016/s0960-894x(01)00520-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823