| Literature DB >> 11551464 |
A L Kurtzman1, S Govindarajan, K Vahle, J T Jones, V Heinrichs, P A Patten.
Abstract
Recent developments in directed evolution technologies combined with innovations in robotics and screening methods have revolutionized protein engineering. These methods are being applied broadly to many fields of biotechnology, including chemical engineering, agriculture and human therapeutics. More specifically, DNA shuffling and other methods of genetic recombination and mutation have resulted in the improvement of proteins of therapeutic interest. Optimizing genetic diversity and fitness through iterative directed evolution will accelerate improvements in engineered protein therapeutics.Entities:
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Year: 2001 PMID： 11551464 DOI： 10.1016/s0958-1669(00)00228-7
Source DB: PubMed Journal: Curr Opin Biotechnol ISSN： 0958-1669 Impact factor: 9.740