Effect of glucagon on blood glucose homeostasis in infants of diabetic mothers.

Thirty infants of diabetic mothers (IDM) were randomly selected and divided into 3 groups of 10 babies each. Group A were used as controls. Group B received glucagon 300 mug/kg i.m. and Group C received glucagon 300 mug/kg i.v. at birth. Hypoglycemia developed in 6 infants in Group A and 4 infants in Group B. None of the infants in Group C had hypoglycemia. Mean blood glucose was higher in Group C in the first 3 hours than Group A, and higher in Group B in the first (/2-1 hour. I.v. glucshon, 300 mug/kg when given in the first 15 minutes after birth prevented hypoglycemia in IDM in the first hours of life.

RCT Entities:   Population Interventions Outcomes