Literature DB >> 11550044

The state of cholinergic structures in forebrain of bulbectomized mice.

N V Bobkova1, I V Nesterova, V V Nesterov.   

Abstract

The effects of bulbectomy on the state of basal forebrain cholinergic structures and spatial memory in Morris water maze were studied. Immunostaining with polyclonal antibodies to choline acetyltransferase AB144P revealed decreased density of immunoreactive cells in the horizontal limb of the diagonal band of Broca (55% of control), basal magnocellular preoptic nucleus (58.9%), and the caudate nucleus-putamen complex (68.2%). No significant changes in the vertical limb of the diagonal band of Broca and globus pallidus were observed. These findings and published data allow us to assume that pathology of the olfactory bulb can underlie memory impairment during Alzheimer's disease associated with dysfunction of acetylcholine-synthesizing structures in the forebrain.

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Year:  2001        PMID： 11550044     DOI： 10.1023/a:1017907511482

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  5 in total

1.  Morphofunctional state of neurons in the temporal cortex and hippocampus in relation to the level of spatial memory in rats after ablation of the olfactory bulbs.

Authors:  I V Nesterova; N V Bobkova; N I Medvinskaya; A N Samokhin; I Yu Aleksandrova
Journal:  Neurosci Behav Physiol       Date:  2008-05

2.  Morphofunctional changes in neurons in the temporal cortex of the brain in relation to spatial memory in bulbectomized mice after treatment with mineral ascorbates.

Authors:  N V Bobkova; I V Nesteroval; R Dana; E Dana; V I Nesterov; Yu Aleksandrova; N I Medvinskaya; A N Samokhin
Journal:  Neurosci Behav Physiol       Date:  2004-09

3.  The Y-Box Binding Protein 1 Suppresses Alzheimer's Disease Progression in Two Animal Models.

Authors:  N V Bobkova; D N Lyabin; N I Medvinskaya; A N Samokhin; P V Nekrasov; I V Nesterova; I Y Aleksandrova; O G Tatarnikova; A G Bobylev; I M Vikhlyantsev; M S Kukharsky; A A Ustyugov; D N Polyakov; I A Eliseeva; D A Kretov; S G Guryanov; L P Ovchinnikov
Journal:  PLoS One       Date:  2015-09-22       Impact factor: 3.240

4.  Special function of nestin(+) neurons in the medial septum-diagonal band of Broca in adult rats.

Authors:  Yuhong Zhao; Kaihua Guo; Dongpei Li; Qunfang Yuan; Zhibin Yao
Journal:  Neural Regen Res       Date:  2014-02-01       Impact factor: 5.135

Review 5.  Role of a Heat Shock Transcription Factor and the Major Heat Shock Protein Hsp70 in Memory Formation and Neuroprotection.

Authors:  Olga G Zatsepina; Michael B Evgen'ev; David G Garbuz
Journal:  Cells       Date:  2021-06-29       Impact factor: 6.600
  5 in total

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