Literature DB >> 11550028

Individual sensitivity to genotoxic effects of nickel and antimutagenic activity of ascorbic acid.

I N Perminova1, T A Sinel'shchikova, N I Alekhina, E V Perminova, G D Zasukhina.   

Abstract

Cytotoxicity of nickel compounds was studied by stimulating the repair synthesis of DNA and counting lymphocyte micronuclei in workers of smelting shop of copper-nickel sulfide processing plant. Nickel content in the organism was evaluated by its concentrations in hair. Therapy with ascorbic acid (1 g/day for 1 month) led to a significant decrease in the number of micronuclei. The number of micronuclei before and after ascorbic acid treatment varied within a wide range in different individuals.

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Year:  2001        PMID: 11550028     DOI: 10.1023/a:1017912521543

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  2 in total

1.  The association between splenocyte apoptosis and alterations of Bax, Bcl-2 and caspase-3 mRNA expression, and oxidative stress induced by dietary nickel chloride in broilers.

Authors:  Jianying Huang; Hengmin Cui; Xi Peng; Jing Fang; Zhicai Zuo; Junliang Deng; Bangyuan Wu
Journal:  Int J Environ Res Public Health       Date:  2013-12-17       Impact factor: 3.390

2.  Toxic effect of NiCl2 on development of the bursa of Fabricius in broiler chickens.

Authors:  Shuang Yin; Hengmin Cui; Xi Peng; Jing Fang; Zhicai Zuo; Junliang Deng; Xun Wang; Bangyuan Wu; Hongrui Guo
Journal:  Oncotarget       Date:  2016-01-05
  2 in total

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