Literature DB >> 11550024

Retinal degeneration under the effect of antibodies to recoverin.

A V Bazhin1, O S Slepova, N K Tikhomirova.   

Abstract

Serious changes in the retina, diagnosed as retinal degeneration and uveitis, are observed only in the presence of high titers of antibodies to recoverin (Ca2+-binding protein, a paraneoplastic antigen) in the blood of rabbits. Negligible changes in the retina of rabbits with low antibody titers are detected only by cytohistochemical analysis of the retina. No changes in the retina develop in rabbits intravenously injected with antibodies to recoverin.

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Year:  2001        PMID: 11550024     DOI: 10.1023/a:1017952102887

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN: 0007-4888            Impact factor:   0.804


  1 in total

1.  Intravenously administered anti-recoverin antibody alone does not pass through the blood-retinal barrier.

Authors:  Jeong Hun Kim; Jin Hyoung Kim; Dong Hun Kim; Woong-Yang Park; Kyu-Won Kim; Young Suk Yu
Journal:  Korean J Ophthalmol       Date:  2011-05-24
  1 in total

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