Literature DB >> 11549453

Derivatives of (2R,3R,4S)-2-aminomethylpyrrolidine-3,4-diol are selective alpha-mannosidase inhibitors.

F Popowycz1, S Gerber-Lemaire, R Demange, E Rodriguez-García, A T Asenjo, I Robina, P Vogel.   

Abstract

A collection of (2R,3R,4S)-3,4-dihydroxypyrrolidin-2-yl derivatives have been tested for their inhibitory activities toward 25 glycosidases. Competitive (K(i)=7.4 microM) and selective inhibition of alpha-mannosidase from jack bean has been found for (2R,3R,4S)-2-[(benzylamino)methyl]pyrrolidine-3,4-diol and other derivatives.

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Year:  2001        PMID： 11549453     DOI： 10.1016/s0960-894x(01)00477-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions.

Authors:  Sameer P Kawatkar; Douglas A Kuntz; Robert J Woods; David R Rose; Geert-Jan Boons
Journal:  J Am Chem Soc       Date:  2006-06-28       Impact factor: 15.419

2.  1-Hydroxymethyl-4-phenylsulfonybutadiene, a versatile building block for the synthesis of 2,3,4-trisusbtituted tetrahydrothiophenes.

Authors:  David Díez; M Templo Benéitez; Isidro S Marcos; N M Garrido; P Basabe; Julio G Urones
Journal:  Molecules       Date:  2004-04-30       Impact factor: 4.411

3.  The molecular basis of inhibition of Golgi alpha-mannosidase II by mannostatin A.

Authors:  Douglas A Kuntz; Wei Zhong; Jun Guo; David R Rose; Geert-Jan Boons
Journal:  Chembiochem       Date:  2009-01-26       Impact factor: 3.164

4.  Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors.

Authors:  Jorge Franco; Francesco Piacente; Melanie Walter; Simone Fratta; Moustafa Ghanem; Andrea Benzi; Irene Caffa; Alexander V Kurkin; Andrea Altieri; Patrick Herr; Macarena Martínez-Bailén; Inmaculada Robina; Santina Bruzzone; Alessio Nencioni; Alberto Del Rio
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-12
  4 in total

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