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Literature DB >> 11549435

G-quadruplex DNA binding by a series of carbocyanine dyes.

S M Kerwin¹, D Sun, J T Kern, A Rangan, P W Thomas.

Abstract

We have examined a number of carbocyanine dyes for their ability to bind intramolecular G-quadruplex DNA structures (G4'-DNA) using a Taq polymerase stop assay. Of the five dyes examined, only one, N,N'-diethylthiacarbocyanine iodide (DTC), was found to bind to G4'-DNA. DTC was also the only dye found to inhibit human telomerase at 50 microM concentration.

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Year: 2001 PMID： 11549435 DOI： 10.1016/s0960-894x(01)00490-5

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

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Cited

7 in total

1. Noncovalent binding and fluorogenic response of cyanine dyes to DNA homoquadruplex and PNA-DNA heteroquadruplex structures.

Authors: Halimatu S Mohammed; Junriz O Delos Santos; Bruce A Armitage
Journal: Artif DNA PNA XNA Date: 2011-04

2. Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.

Authors: Carolyn L Mazzitelli; Jennifer S Brodbelt; Jonathan T Kern; Mireya Rodriguez; Sean M Kerwin
Journal: J Am Soc Mass Spectrom Date: 2006-02-28 Impact factor: 3.109

3. Second Generation G-Quadruplex Stabilizing Trimethine Cyanines.

Authors: Eric A Owens; Hang T Huynh; Ekaterina M Stroeva; Arghya Barman; Kostiantyn Ziabrev; Ananya Paul; Sarah V Nguyen; Matthew Laramie; Donald Hamelberg; Markus W Germann; W David Wilson; Maged Henary
Journal: Bioconjug Chem Date: 2019-09-26 Impact factor: 4.774

G-quadruplex DNA binding by a series of carbocyanine dyes.

1. Noncovalent binding and fluorogenic response of cyanine dyes to DNA homoquadruplex and PNA-DNA heteroquadruplex structures.

2. Evaluation of binding of perylene diimide and benzannulated perylene diimide ligands to DNA by electrospray ionization mass spectrometry.

3. Second Generation G-Quadruplex Stabilizing Trimethine Cyanines.

4. Targeting G-quadruplex DNA with synthetic dendritic peptide: modulation of the proliferation of human cancer cells.

5. Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA.

6. An exonuclease I hydrolysis assay for evaluating G-quadruplex stabilization by small molecules.

7. Selective G-quadruplex DNA recognition by a new class of designed cyanines.