| Literature DB >> 11549401 |
D Marazziti1, L Dell'Osso, A Rossi, I Masala, S Baroni, A Armani, G Giannaccini, E Di Nasso, A Lucacchini, G B Cassano.
Abstract
Research to date would suggest the possible involvement of the serotonin (5-HT) system in the pathophysiology of suicide. With this study, we aimed to investigate the platelet 5-HT transporter, by means of the specific binding of tritiated paroxetine ([3H]Par), in a sample of 20 suicide attempters recruited at a first-aid service, as compared with healthy control subjects and psychiatric patients with no current or previous history of suicide attempt. The results, showing a decreased number of [3H]Par binding sites in suicide attempters, would suggest the involvement of the presynaptic 5-HT transporter in self-aggressive behavior.Entities:
Mesh：
Substances：
Year: 2001 PMID： 11549401 DOI： 10.1016/s0165-1781(01)00281-5
Source DB: PubMed Journal: Psychiatry Res ISSN： 0165-1781 Impact factor: 3.222