[Characteristics of the spatio-temporal organization of the P300 component of AEP during the "active" and "passive" stimulus perception in healthy subjects].

The concern of the work was in detection and analysis of P300 component of the acoustic evoked potential in healthy subjects in different experimental situations. During counting the rare sounds, P300 was most pronounced in the frontocentral and parietooccipital areas mainly of the left-hemisphere. The response shape was correlated with characteristics of the basic rhythm of the background EEG. Responses of simple and complex shapes were distinguished. The simplest responses were recorded in subjects with hypersynchronous alpha-rhythm. Analysis of three-dimensional dipole source localization showed that structures of the brainstem, limbic system, and frontal lobes participate in generation of the wave. In all the subjects, the decisive role in response generation was played by the brainstem structures. In persons with hypersynchronous alpha-rhythm, the contribution of the frontal lobes was less pronounced. During "passive" listening of sounds, P300 parameters significantly differed from those observed during counting only in 46% of cases (in persons having no hypersynchronous alpha-rhythm). A simplification of the response shape during "passive" listening was observed in these cases, the area of the maximal response expression was shifted to symmetrical areas of the right-hemisphere, the number of dipole sources reduced due to a decrease in the contribution of the frontal and limbic structures into the response generation.