Literature DB >> 11547922

Role of the omentum in the treatment of Alzheimer's disease.

H S Goldsmith1.   

Abstract

Beneficial post-operative changes in Alzheimer patients have been observed following omentum transposition to the brain. It is believed that these changes are to a certain degree due to the omentum's ability to increase cerebral blood flow (CBF). Since the omentum is known to increase CBF and to have angiogenic, neurotransmitters and nerve growth substances in its tissues, it is theorized that these biological factors favorably affect still viable but deteriorating ischemic-sensitive neurons located within the Alzheimer brain. Being able to 'rescue' these neurons by increasing CBF and adding neurotrophic factors from the omentum are mechanisms which are believed to increase neuronal energy (ATP production) which leads to cognitive improvement.

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Year:  2001        PMID: 11547922     DOI: 10.1179/016164101101198893

Source DB:  PubMed          Journal:  Neurol Res        ISSN: 0161-6412            Impact factor:   2.448


  7 in total

Review 1.  Omentum and bone marrow: how adipocyte-rich organs create tumour microenvironments conducive for metastatic progression.

Authors:  H Chkourko Gusky; J Diedrich; O A MacDougald; I Podgorski
Journal:  Obes Rev       Date:  2016-07-19       Impact factor: 9.213

2.  Binswanger disease may benefit from omental arteries.

Authors:  Harry S Goldsmith
Journal:  Surg Neurol Int       Date:  2015-01-07

3.  Alzheimer's disease can be treated: Why the delay?

Authors:  Harry S Goldsmith
Journal:  Surg Neurol Int       Date:  2017-07-07

Review 4.  Roles of omental and bone marrow adipocytes in tumor biology.

Authors:  Yoon Jin Cha; Ja Seung Koo
Journal:  Adipocyte       Date:  2019-12       Impact factor: 4.534

5.  Cardiovascular risk factors promote brain hypoperfusion leading to cognitive decline and dementia.

Authors:  Jack C de la Torre
Journal:  Cardiovasc Psychiatry Neurol       Date:  2012-12-03

Review 6.  Biocompatible Peritoneal Dialysis: The Target Is Still Way Off.

Authors:  Maria Bartosova; Claus Peter Schmitt
Journal:  Front Physiol       Date:  2019-01-07       Impact factor: 4.566

7.  Alzheimer's Disease: A Decreased Cerebral Blood Flow to Critical Intraneuronal Elements Is the Cause.

Authors:  Harry S Goldsmith
Journal:  J Alzheimers Dis       Date:  2022       Impact factor: 4.472

  7 in total

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