Literature DB >> 11547916

Lutropin receptor function: insights from natural, engineered, and computer-simulated mutations.

F Fanelli1, A P Themmen, D Puett.   

Abstract

The lutropin receptor is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimer glycoprotein hormone family. As reviewed herein, comparative analyses of natural, engineered, and computer-simulated mutations of the lutropin receptor have provided considerable insight into the molecular basis of receptor function.

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Year:  2001        PMID： 11547916     DOI： 10.1080/152165401753544214

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  10 in total

1.  Bioluminescence resonance energy transfer studies reveal constitutive dimerization of the human lutropin receptor and a lack of correlation between receptor activation and the propensity for dimerization.

Authors:  Rongbin Guan; Xiuyan Feng; Xueqing Wu; Meilin Zhang; Xuesen Zhang; Terence E Hébert; Deborah L Segaloff
Journal:  J Biol Chem       Date:  2009-01-15       Impact factor: 5.157

Review 2.  Constitutively active luteinizing hormone receptors: consequences of in vivo expression.

Authors:  Thomas P Meehan; Prema Narayan
Journal:  Mol Cell Endocrinol       Date:  2006-10-12       Impact factor: 4.102

Review 3.  The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.

Authors:  Slawomir Filipek; David C Teller; Krzysztof Palczewski; Ronald Stenkamp
Journal:  Annu Rev Biophys Biomol Struct       Date:  2003-02-05

4.  A cell surface inactive mutant of the human lutropin receptor (hLHR) attenuates signaling of wild-type or constitutively active receptors via heterodimerization.

Authors:  Meilin Zhang; Xiuyan Feng; Rongbin Guan; Terence E Hébert; Deborah L Segaloff
Journal:  Cell Signal       Date:  2009-07-16       Impact factor: 4.315

5.  Impact of a constitutively active luteinizing hormone receptor on testicular gene expression and postnatal Leydig cell development.

Authors:  Mary M Coonce; Amanda C Rabideau; Stacey McGee; Keriayn Smith; Prema Narayan
Journal:  Mol Cell Endocrinol       Date:  2008-11-01       Impact factor: 4.102

Review 6.  A functional transmembrane complex: the luteinizing hormone receptor with bound ligand and G protein.

Authors:  D Puett; Y Li; G DeMars; K Angelova; F Fanelli
Journal:  Mol Cell Endocrinol       Date:  2006-10-23       Impact factor: 4.102

Review 7.  Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling.

Authors:  Francesca Fanelli; Pier G De Benedetti
Journal:  J Comput Aided Mol Des       Date:  2006-09-29       Impact factor: 4.179

Review 8.  Biological functions of hCG and hCG-related molecules.

Authors:  Laurence A Cole
Journal:  Reprod Biol Endocrinol       Date:  2010-08-24       Impact factor: 5.211

9.  Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation.

Authors:  Travis J O'Brien; Mariah M Kalmin; Arthur F Harralson; Adam M Clark; Ian Gindoff; Samuel J Simmens; David Frankfurter; Paul Gindoff
Journal:  Reprod Biol Endocrinol       Date:  2013-07-25       Impact factor: 5.211

Review 10.  Structural aspects of luteinizing hormone receptor: information from molecular modeling and mutagenesis.

Authors:  Francesca Fanelli; David Puett
Journal:  Endocrine       Date:  2002-08       Impact factor: 3.633
  10 in total

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