| Literature DB >> 11545734 |
V Stambolic1, D MacPherson, D Sas, Y Lin, B Snow, Y Jang, S Benchimol, T W Mak.
Abstract
PTEN tumor suppressor is frequently mutated in human cancers and is a negative regulator of PI3'K/PKB/Akt-dependent cellular survival. Investigation of the human genomic PTEN locus revealed a p53 binding element directly upstream of the PTEN gene. Deletion and mutation analyses showed that this element is necessary for inducible transactivation of PTEN by p53. A p53-independent element controlling constitutive expression of PTEN was also identified. In contrast to p53 mutant cell lines, induction of p53 in primary and tumor cell lines with wild-type p53 increased PTEN mRNA levels. PTEN was required for p53-mediated apoptosis in immortalized mouse embryonic fibroblasts. Our results reveal a unique role for p53 in regulation of cellular survival and an interesting connection in tumor suppressor signaling.Entities:
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Year: 2001 PMID： 11545734 DOI： 10.1016/s1097-2765(01)00323-9
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970