C Chan1, J O'Day. 1. The Royal Victorian Eye and Ear Hospital, Melbourne, Australia. chunkeng@yahoo.com
Abstract
PURPOSE: To discuss the autoimmune basis of melanoma-associated retinopathy (MAR) and its implications for management and prognosis. METHODS: An unusual history of a woman with melanoma-associated retinopathy is presented in detail. A review of published reports and a summary of 19 reported cases of MAR provide a basis for discussion. RESULTS: This case report and other published reports highlight a number of points regarding MAR including the male predominance, prolonged survival in several patients and lack of response to immunosuppression. CONCLUSIONS: Melanoma-associated retinopathy may prolong the survival of patients with metastatic melanoma through the autoimmune response. Therefore, treatment of visual symptoms with immunosuppression needs to be considered carefully.
PURPOSE: To discuss the autoimmune basis of melanoma-associated retinopathy (MAR) and its implications for management and prognosis. METHODS: An unusual history of a woman with melanoma-associated retinopathy is presented in detail. A review of published reports and a summary of 19 reported cases of MAR provide a basis for discussion. RESULTS: This case report and other published reports highlight a number of points regarding MAR including the male predominance, prolonged survival in several patients and lack of response to immunosuppression. CONCLUSIONS:Melanoma-associated retinopathy may prolong the survival of patients with metastatic melanoma through the autoimmune response. Therefore, treatment of visual symptoms with immunosuppression needs to be considered carefully.
Authors: Robert M Duvoisin; Gaoying Ren; Tammie L Haley; Matthew H Taylor; Catherine W Morgans Journal: Invest Ophthalmol Vis Sci Date: 2019-05-01 Impact factor: 4.799
Authors: Lorenzo Uccellini; Valeria De Giorgi; Yingdong Zhao; Barbara Tumaini; Narnygerel Erdenebileg; Mark E Dudley; Sara Tomei; Davide Bedognetti; Maria Libera Ascierto; Qiuzhen Liu; Richard Simon; Leah Kottyan; Kenneth M Kaufman; John B Harley; Ena Wang; Steven A Rosenberg; Francesco M Marincola Journal: J Transl Med Date: 2012-08-21 Impact factor: 5.531
Authors: Steven K Lundy; Enayat Nikoopour; Athanasios J Karoukis; Ray Ohara; Mohammad I Othman; Rebecca Tagett; K Thiran Jayasundera; John R Heckenlively Journal: Front Med (Lausanne) Date: 2018-09-13