| Literature DB >> 11545205 |
N Takahashi1, Y Fujibayashi, Y Yonekura, M J Welch, A Waki, T Tsuchida, N Sadato, K Sugimoto, A Nakano, J D Lee, H Itoh.
Abstract
Copper-62 labeled diacetyl-bis(N4-methylthiosemicarbazone) (62Cu-ATSM) has been proposed as a generator produced positron-emitting tracer for hypoxic tissue imaging. To clarify the usefulness of 62Cu-ATSM for myocardial ischemia, 62Cu-ATSM PET was performed in 7 patients with coronary artery disease. Increased myocardial uptake of 62Cu-ATSM was observed (myocardium/blood ratio: 3.09) in one patient with unstable angina, who had increased 18F-fluorodeoxyglucose (18F-FDG) uptake under the fasting condition. The other 6 patients, who were clinically stable, did not have increased 62Cu-ATSM uptake, although abnormal 18F-FDG uptake was seen in 4 patients. This preliminary study suggests that 62Cu-ATSM is a promising PET tracer for hypoxic imaging in acute ischemia.Entities:
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Year: 2001 PMID： 11545205 DOI： 10.1007/bf02987849
Source DB: PubMed Journal: Ann Nucl Med ISSN： 0914-7187 Impact factor: 2.668