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Literature DB >> 1154453

Serum testosterone and dihydrotestosterone changes with age in rat.

Abstract

Serum testosterone (T) and 5alpha-dihydrotestosterone (DHT) were measured in young, adult and old Albino Wistar male rats using a sensitive and reliable radioimmunoassay, after separating T from DHT by thin layer chromatography. The mean plus or minus S.E.M. for T in young, adult and old rats were 62 plus or minus 11, 250 plus or minus 27 and 125 plus or minus 25 (ng/100 ml) respectively. Serum T was increased in adults (P less than 0.001) and decreased in old rats (P less than 0.01). The mean plus or minus S.E.M. for serum DHT was 8 plus or minus 2, 19 plus or minus 2 and 17 plus or minus 1 (ng/100 ml) for young, adult and old rats respectively. DHT was increased in adults (P less than 0.001), but did not change in old rats.

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Year: 1975 PMID： 1154453 DOI： 10.1016/0039-128x(75)90039-2

Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668

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Cited

13 in total

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Authors: Mary Behan; Julie M Wenninger
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2. Advanced carcinoma of the prostate: treatment with a gonadotrophin releasing hormone agonist.

Authors: J M Allen; J P O'Shea; K Mashiter; G Williams; S R Bloom
Journal: Br Med J (Clin Res Ed) Date: 1983-05-21

3. The effect of ageing on the histochemically demonstrable catecholamines in the hypogastric (main pelvic) ganglion of the rat.

Authors: M Partanen; R M Santer; A Hervonen
Journal: Histochem J Date: 1980-09

4. Temperature lability and cAMP-dependent protein kinase activation of cholesteryl ester hydrolase as a function of age in developing rat testis.

Authors: S F Wee; W M Grogan
Journal: Lipids Date: 1989-09 Impact factor: 1.880

10. Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats.

Authors: Richard N Ranson; Jennifer H Connelly; Robert M Santer; Alan H D Watson
Journal: Anat Cell Biol Date: 2012-12-14

Serum testosterone and dihydrotestosterone changes with age in rat.

Review 1. Sex steroidal hormones and respiratory control.

2. Advanced carcinoma of the prostate: treatment with a gonadotrophin releasing hormone agonist.

3. The effect of ageing on the histochemically demonstrable catecholamines in the hypogastric (main pelvic) ganglion of the rat.

4. Temperature lability and cAMP-dependent protein kinase activation of cholesteryl ester hydrolase as a function of age in developing rat testis.

5. Androgen regulates brain-derived neurotrophic factor in spinal motoneurons and their target musculature.

6. The effect of previous endocrine therapy on responses to a single dose of an LHRH analogue.

Review 7. Brain-derived neurotrophic factor and androgen interactions in spinal neuromuscular systems.

8. Urinary unconjugated 5 alpha-androstane-3 alpha, 17 beta-diol in patients with prostatic tumours.

9. Age-related adaptation of bone-PDL-tooth complex: Rattus-Norvegicus as a model system.

10. Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats.