| Literature DB >> 11542721 |
S A Benner1, T R Battersby, B Eschgfaller, D Hutter, J T Kodra, S Lutz, T Arslan, D K Baschlin, M Blattler, M Egli, C Hammer, H A Held, J Horlacher, Z Huang, B Hyrup, T F Jenny, S C Jurczyk, M Konig, U von Krosigk, M J Lutz, L J MacPherson, S E Moroney, E Muller, K P Nambiar, J A Piccirilli, C Y Switzer, J J Vogel, C Richert, A L Roughton, J Schmidt, K C Schneider, J Stackhouse.
Abstract
A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did.Entities:
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Year: 1998 PMID： 11542721 DOI： 10.1351/pac199870020263
Source DB: PubMed Journal: Pure Appl Chem ISSN： 0033-4545 Impact factor: 2.453