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Literature DB >> 11542079

Oligomerization of 3'-amino-3'deoxyguanosine-5'phosphorimidazolidate on a d(CpCpCpCpC) template.

M Tohidi¹, W S Zielinski, C H Chen, L E Orgel.

Abstract

3'-Amino-3'-deoxyguanosine-5'-phosphorimidazolidate (ImpGNH2) oligomerizes more rapidly and regiospecifically than related nucleotide derivatives on a d(CpCpCpCpC) template. The greater nucleophilicity of the amino group leads to efficient oligomerization even when the structure of the double-helical complex formed by the template and the substrate is not optimal for reaction. The use of amine-containing analogues should permit us to develop models of potentially prebiotic polymerization reactions that cannot be studied easily using natural nucleotides.

Keywords: NASA Discipline Exobiology; Non-NASA Center

Mesh：

Substances：

Year: 1987 PMID： 11542079 DOI： 10.1007/bf02101750

Source DB: PubMed Journal: J Mol Evol ISSN： 0022-2844 Impact factor: 2.395

3 in total

1. Template-directed synthesis on oligodeoxycytidylate and polydeoxycytidylate templates.

Authors: C B Chen; T Inoue; L E Orgel
Journal: J Mol Biol Date: 1985-01-20 Impact factor: 5.469

2. Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model.

Authors: T Inoue; L E Orgel
Journal: J Mol Biol Date: 1982-11-25 Impact factor: 5.469

3. Oligomerization of activated derivatives of 3'-amino-3'-deoxyguanosine on poly(C) and poly(dC) templates.

Authors: W S Zielinski; L E Orgel
Journal: Nucleic Acids Res Date: 1985-04-11 Impact factor: 16.971

3 in total

8 in total

1. Template-directed synthesis of oligonucleotides under eutectic conditions.

Authors: R Stribling; S L Miller
Journal: J Mol Evol Date: 1991 Impact factor: 2.395

Review 2. The origins of cellular life.

Authors: Jason P Schrum; Ting F Zhu; Jack W Szostak
Journal: Cold Spring Harb Perspect Biol Date: 2010-05-19 Impact factor: 10.005

Oligomerization of 3'-amino-3'deoxyguanosine-5'phosphorimidazolidate on a d(CpCpCpCpC) template.

1. Template-directed synthesis on oligodeoxycytidylate and polydeoxycytidylate templates.

2. Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model.

3. Oligomerization of activated derivatives of 3'-amino-3'-deoxyguanosine on poly(C) and poly(dC) templates.

1. Template-directed synthesis of oligonucleotides under eutectic conditions.

Review 2. The origins of cellular life.

3. Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.

Review 4. Membrane transport in primitive cells.

5. Fast and accurate nonenzymatic copying of an RNA-like synthetic genetic polymer.

6. The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA.

7. Template-directed synthesis of a genetic polymer in a model protocell.

8. Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension.