Endometrial regeneration and adhesion formation.

The implantation of fibroblasts over the denuded endometrium in rabbit and rat uteri was followed by the inhibition of endometrial regeneration. The fibroblast proliferation led to development of intra-uterine adhesions and endometrial fibrosis. These observations were the rationale behind a clinical trial which attempted to reduce uterine blood loss by the replacement of the endometrium by connective tissue.