| Literature DB >> 11539994 |
E L Alpen1, P Powers-Risius, S B Curtis, R DeGuzman, R J Fry.
Abstract
Neoplasia in the rodent Harderian gland has been used to determine the carcinogenic potential of irradiation by HZE particles. Ions from protons to lanthanum at energies up to 670 MeV/a have been used to irradiate mice, and prevalence of Harderian gland tumors has been measured 16 months after irradiation. The RBE for tumor induction has been expressed as the RBEmax, which is the ratio of the initial slopes of the dose vs prevalence curve. The RBEmax has been found to be approximately 30 for ions with LET values in excess of 100 keV/micrometer. Analysis on the basis of fluence as a substitute for dose has shown that on a per particle basis all of the ions with LET values in excess of 100 keV/micrometer have equal effectiveness. An analysis of the probabilities of ion traversals of the nucleus has shown that for these high stopping powers that a single hit is effective in producing neoplastic transformation.Entities:
Keywords: NASA Discipline Number 04-10; NASA Discipline Radiation Health; NASA Program Radiation Health; Non-NASA Center
Mesh：
Substances：
Year: 1994 PMID： 11539994 DOI： 10.1016/0273-1177(94)90512-6
Source DB: PubMed Journal: Adv Space Res ISSN： 0273-1177 Impact factor: 2.152