| Literature DB >> 1153863 |
M D Rayner, B J Sanders, S M Harris, Y C Lin, B E Morton.
Abstract
Palytoxin (PTX) inhibited phasic tension production and initiated tonic contracture in isolated paced ventricle strips at concentrations greater than 10(-10) M. PTX-induced contracture was associated with increased 45Ca2+ uptake. PTX-induced additional 45Ca2+ uptake was completely blocked by 2 mM La3+. All observed PTX effects were enhanced by elevation of [Ca2+] o from 1.9 to 6 mM and this threefold increase in [Ca2+] o resulted in a threefold increase in isotope-determined Ca2+ uptake in presence of 10(-8) M PTX. It is concluded that the observed effects of PTX could be mediated by an increase in calcium permeability of myocardial cells.Entities:
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Year: 1975 PMID： 1153863
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164