Literature DB >> 11536860

Studies on order in prebiological systems at the Laboratory of Chemical Evolution.

M K Hobish.   

Abstract

The basic tenet of investigations in the Laboratory of Chemical Evolution (LCE) under Cyril Ponnamperuma was that biology is a recapitulation of prebiology, and that protobiology is an outcome of simple molecular interactions, engendered by the physics and chemistry of the molecules themselves. Studies were undertaken to continue research into understanding the determining physical and chemical parameters of molecular interactions leading to increasing complexity in pre- and proto-biological systems. Among other, related work, research was performed on the origin of the genetic code, the origin of order in prebiotic polymers, and related studies on the origins of optical activity in biological macromolecules. Highlights of some these studies are presented here.

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Year:  1998        PMID: 11536860     DOI: 10.1023/a:1006520106159

Source DB:  PubMed          Journal:  Orig Life Evol Biosph        ISSN: 0169-6149            Impact factor:   1.950


  16 in total

Review 1.  APPLICATION OF NUCLEAR MAGNETIC RESONANCE IN BIOCHEMISTRY.

Authors:  A KOWALSKY; M COHN
Journal:  Annu Rev Biochem       Date:  1964       Impact factor: 23.643

2.  Nuclear magnetic resonance studies of proteins.

Authors:  A KOWALSKY
Journal:  J Biol Chem       Date:  1962-06       Impact factor: 5.157

3.  Nonrandomness in prebiotic peptide synthesis.

Authors:  S Tyagi; C Ponnamperuma
Journal:  J Mol Evol       Date:  1990-05       Impact factor: 2.395

4.  Evidence for the interaction of nucleotides with immobilized amino-acids and its significance for the origin of the genetic code.

Authors:  C Saxinger; C Ponnamperuma; C Woese
Journal:  Nat New Biol       Date:  1971-12-08

Review 5.  Experimental studies related to the origin of the genetic code and the process of protein synthesis--a review.

Authors:  J C Lacey; D W Mullins
Journal:  Orig Life       Date:  1983-03

6.  The evolution of the protein synthesis system. I. A model of a primitive protein synthesis system.

Authors:  H Mizutani; C Ponnamperuma
Journal:  Orig Life       Date:  1977-10

7.  Separation of D and L amino acids by liquid chromatography: use of chiral eluants.

Authors:  P E Hare; E Gil-Av
Journal:  Science       Date:  1979-06-15       Impact factor: 47.728

8.  Crystallization of thermostable glyceraldehyde-3-phosphate dehydrogenase from Bacillus stearothermophilus.

Authors:  R E Amelunxen
Journal:  Biochim Biophys Acta       Date:  1966-08-10

9.  Binding of tryptamine and 5-hydroxytryptamine (serotonin) to nucleic acids. Fluorescence and proton magnetic resonance studies.

Authors:  C Hélène; J L Dimicoli; F Brun
Journal:  Biochemistry       Date:  1971-09-28       Impact factor: 3.162

10.  L Amino acids and D-glucose bind stereospecifically to a colloidal clay.

Authors:  S C Bondy; M E Harrington
Journal:  Science       Date:  1979-03-23       Impact factor: 47.728

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