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Literature DB >> 11536677

Speculations on the evolution of the genetic code IV. The evolution of the aminoacyl-tRNA synthetases.

Abstract

An evolutionary scheme is postulated in which a primitive code, involving only guanine and cytosine, would code for glycine(GG.), alanine(GC.), arginine(CG.) and proline(CC.). There evolves from this primitive code families of related amino acids as the code expands. The evolution of the aminoacyl-tRNA synthetases are considered to be indicators for the evolution of the genetic code. The postulated model for the evolution of the genetic code is used to give an evolutionary interpretation to the recent work on the structure and sequences of the aminoacyl-tRNA synthetases.

Entities: Chemical

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Year: 1995 PMID： 11536677 DOI： 10.1007/bf01581589

Source DB: PubMed Journal: Orig Life Evol Biosph ISSN： 0169-6149 Impact factor: 1.950

13 in total

Speculations on the evolution of the genetic code IV. The evolution of the aminoacyl-tRNA synthetases.

Review 1. Structural and functional relationships between aminoacyl-tRNA synthetases.

2. Cysteinyl-tRNA synthetase is a direct descendant of the first aminoacyl-tRNA synthetase.

Review 3. Aminoacylation of RNA oligonucleotides: minimalist structures and origin of specificity.

Review 4. Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases.

5. Speculations on the evolution of the genetic code III: The evolution of t-RNA.

6. Amino acid composition of proteins: Selection against the genetic code.

7. Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.

8. Primary structure of the gene for glycyl-tRNA synthetase from Bombyx mori.

9. Speculations on the evolution of the genetic code. II.

10. Sequence determination and modeling of structural motifs for the smallest monomeric aminoacyl-tRNA synthetase.

Review 1. The case for an error minimizing standard genetic code.

2. Signature of a primitive genetic code in ancient protein lineages.

Review 3. Speculations on the origin of the genetic code.

4. The primordial tRNA acceptor stem code from theoretical minimal RNA ring clusters.