Literature DB >> 11536389

Neuroprotective effects of Withania somnifera Dunn. in hippocampal sub-regions of female albino rat.

S Jain1, S D Shukla, K Sharma, M Bhatnagar.   

Abstract

The neuroprotective effects of W. somnifera were studied on stressed adult female Swiss albino rats. Experimental rats were subjected to immobilization stress for 14 h and were treated with a root powder extract of W. somnifera available as Stresscom capsules (Dabur India Ltd). Control rats were maintained in completely, non stressed conditions. Thionin stained serial coronal sections (7 microm) of brain passing through the hippocampal region of stressed rats (E(1) group) demonstrated 85% degenerating cells (dark cells and pyknotic cells) in the CA(2) and CA(3) sub-areas. Treatment with W. somnifera root powder extract significantly reduced (80%) the number of degenerating cells in both the areas. The study thus demonstrates the antistress neuroprotective effects of W. somnifera. Copyright 2001 John Wiley & Sons, Ltd.

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Year:  2001        PMID： 11536389     DOI： 10.1002/ptr.802

Source DB:  PubMed          Journal:  Phytother Res        ISSN： 0951-418X            Impact factor:   5.878


  18 in total

1.  Neuroprotective effects of Withania somnifera dunal.: A possible mechanism.

Authors:  Maheep Bhatnagar; Durgesh Sharma; Mahendra Salvi
Journal:  Neurochem Res       Date:  2009-05-15       Impact factor: 3.996

2.  Withania somnifera prevents morphine withdrawal-induced decrease in spine density in nucleus accumbens shell of rats: a confocal laser scanning microscopy study.

Authors:  Sanjay Kasture; Stefania Vinci; Federico Ibba; Alessandro Puddu; Mara Marongiu; Balasubramanian Murali; Augusta Pisanu; Daniele Lecca; Gerald Zernig; Elio Acquas
Journal:  Neurotox Res       Date:  2009-06-24       Impact factor: 3.911

3.  Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial.

Authors:  Dnyanraj Choudhary; Sauvik Bhattacharyya; Kedar Joshi
Journal:  J Evid Based Complementary Altern Med       Date:  2016-04-06

4.  Assessment of Cholinergic Properties of Ashwagandha Leaf-Extract in the Amnesic Mouse Brain.

Authors:  Akash Gautam; Renu Wadhwa; Mahendra K Thakur
Journal:  Ann Neurosci       Date:  2016-07-07

Review 5.  Pharmacologic overview of Withania somnifera, the Indian Ginseng.

Authors:  Nawab John Dar; Abid Hamid; Muzamil Ahmad
Journal:  Cell Mol Life Sci       Date:  2015-08-26       Impact factor: 9.261

6.  Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells.

Authors:  Elizabeth A Mazzio; David Bauer; Patricia Mendonca; Equar Taka; Karam F A Soliman
Journal:  J Neuroimmunol       Date:  2016-12-01       Impact factor: 3.478

7.  Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity.

Authors:  Hardeep Kataria; Renu Wadhwa; Sunil C Kaul; Gurcharan Kaur
Journal:  PLoS One       Date:  2012-05-14       Impact factor: 3.240

8.  Glioprotective effects of Ashwagandha leaf extract against lead induced toxicity.

Authors:  Praveen Kumar; Raghavendra Singh; Arshed Nazmi; Dinesh Lakhanpal; Hardeep Kataria; Gurcharan Kaur
Journal:  Biomed Res Int       Date:  2014-05-28       Impact factor: 3.411

9.  β-Amyloid1-42, HIV-1Ba-L (clade B) infection and drugs of abuse induced degeneration in human neuronal cells and protective effects of ashwagandha (Withania somnifera) and its constituent Withanolide A.

Authors:  Kesava Rao Venkata Kurapati; Thangavel Samikkannu; Venkata Subba Rao Atluri; Elena Kaftanovskaya; Adriana Yndart; Madhavan P N Nair
Journal:  PLoS One       Date:  2014-11-21       Impact factor: 3.240

10.  Ashwagandha (Withania somnifera) reverses β-amyloid1-42 induced toxicity in human neuronal cells: implications in HIV-associated neurocognitive disorders (HAND).

Authors:  Kesava Rao Venkata Kurapati; Venkata Subba Rao Atluri; Thangavel Samikkannu; Madhavan P N Nair
Journal:  PLoS One       Date:  2013-10-16       Impact factor: 3.240
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