| Literature DB >> 11536228 |
M Costa-Mattioli1, S Monpoeho, C Schvoerer, B Besse, M H Aleman, S Billaudel, J Cristina, V Ferré.
Abstract
Genetic analysis of selected genome regions of hepatitis A Virus (HAV) suggested that distinct genotype could be defined in different geographic locations. In order to study the degree of genetic variability among HAV isolated during a single epidemic outbreak, sequences from a 148 base pair segment within the VP1 amino terminal region were obtained for eight distinct HAV isolates from an outbreak that occurred in North Bretagne (France). These sequences were compared among themselves and with published sequences from 30 different strains that represented different HAV sub-genotypes that were isolated all over the world. Phylogenetic analysis revealed an extensive genetic heterogeneity among strains belonging to the same outbreak and revealed co-circulation of sub-genotype IA, IB, and the presence of IIIA sub-genotype for the first time in a Mediterranean country. Copyright 2001 Wiley-Liss, Inc.Entities:
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Year: 2001 PMID： 11536228 DOI： 10.1002/jmv.2025
Source DB: PubMed Journal: J Med Virol ISSN： 0146-6615 Impact factor: 2.327