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Literature DB >> 1153608

A genetic analysis of morphine-induced running and analgesia in the mouse.

Abstract

A genetic analysis of morphine-induced analgesia and activity was conducted in mice belonging to the strains BALB/cJ, C57BL/6J, DBA/2J and to their F1 and backcross progenies. The results support previous findings showing that a negative correlation is evident between these two behavioral measures and support that their mode of inheritance is characterized by dominance or partial dominance. The biometric analysis conducted on the parental, F1 hybrid and backcross populations indicates very clearly that the effects of morphine are genetically determined.

Entities: Chemical Disease Species

Mesh：

Substances：
Morphine

Year: 1975 PMID： 1153608 DOI： 10.1007/bf00428924

Source DB: PubMed Journal: Psychopharmacologia

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Cited

12 in total

9. Strain difference in morphine-induced increase in plasma cyclic AMP and cyclic GMP levels in relation to locomotor activity in male mice.

Authors: T Muraki; H Uzumaki; R Kato
Journal: Psychopharmacology (Berl) Date: 1982 Impact factor: 4.530

Review 10. Opioids and behavior: genetic aspects.

Authors: H R Frischknecht; B Siegfried; P G Waser
Journal: Experientia Date: 1988-06-15

A genetic analysis of morphine-induced running and analgesia in the mouse.

1. Strain difference in the effects of morphine on the rectal temperature and respiratory rate in male mice.

2. HS014, a selective melanocortin-4 (MC4) receptor antagonist, modulates the behavioral effects of morphine in mice.

3. Opioid peptides as neuroregulators: potential areas for the study of genetic-behavioral mechanisms.

4. Strain-dependent effects of naloxone on discrimination learning in mice.

5. Genetic analysis of the effects of morphine on plasma cyclic nucleotides and locomotor activity in male mice.

6. Brain mu and delta opioid receptors mediate different locomotor hyperactivity responses of the C57BL/6J mouse.

7. Aggression modulates genetic influences on morphine analgesia as assessed using a classical mendelian cross analysis.

8. Effects of heroin, alone or in combination with other drugs, on the locomotor activity in two inbred strains of mice.

9. Strain difference in morphine-induced increase in plasma cyclic AMP and cyclic GMP levels in relation to locomotor activity in male mice.

Review 10. Opioids and behavior: genetic aspects.