Literature DB >> 11536015

Endogenous and exogenous ARC in serum withdrawal mediated PC12 cell apoptosis: a new pro-apoptotic role for ARC.

T A Dowds1, E L Sabban.   

Abstract

The role of ARC (Apoptosis Repressor with Caspase Recruitment Domain) in PC12 cell serum withdrawal driven apoptosis was studied. A progressive and massive increase in ARC protein occurs during serum withdrawal that correlates with declining survival and processing of caspase-2, previously shown to associate with ARC. This accumulation of ARC occurs in a transcriptional and translational independent manner. Additionally, ARC is localized exclusively in the nucleus of PC12 cells. Furthermore, transfection of PC12 cells with hARC-Flag promotes death and fails to protect the cells from apoptosis by serum withdrawal. Therefore, ARC functions in a pro-apoptotic manner in PC12 cell serum withdrawal induced apoptosis.

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Year:  2001        PMID： 11536015     DOI： 10.1038/sj.cdd.4400855

Source DB:  PubMed          Journal:  Cell Death Differ        ISSN： 1350-9047            Impact factor:   15.828


  5 in total

1.  Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes.

Authors:  Wendy M McKimpson; Yun Chen; James A Irving; Min Zheng; Jeremy Weinberger; Wilson Lek Wen Tan; Zenia Tiang; Alistair M Jagger; Streamson C Chua; Jeffrey E Pessin; Roger S-Y Foo; David A Lomas; Richard N Kitsis
Journal:  Dev Cell       Date:  2021-03-04       Impact factor: 12.270

Review 2.  Apoptosis repressor with caspase recruitment domain, a multifunctional modulator of cell death.

Authors:  Agnieszka H Ludwig-Galezowska; Lorna Flanagan; Markus Rehm
Journal:  J Cell Mol Med       Date:  2011-05       Impact factor: 5.310

3.  Inhibition of ARC promoting the apoptosis of rat pulmonary arterial smooth muscle cells after serum deprivation in vitro.

Authors:  Jie Zhang; Zeyu Wu; Ming Guan; Hongyan Lu; Xuming Mo
Journal:  Mol Med Rep       Date:  2017-07-21       Impact factor: 2.952

4.  Expression of apoptosis repressor with caspase recruitment domain (ARC) in familial adenomatous polyposis (FAP) adenomas and its correlation with DNA mismatch repair proteins, p53, Bcl-2, COX-2 and beta-catenin.

Authors:  Christoph Roser; Csaba Tóth; Marcus Renner; Esther Herpel; Peter Schirmacher
Journal:  Cell Commun Signal       Date:  2021-02-12       Impact factor: 5.712

Review 5.  Role of apoptosis repressor with caspase recruitment domain (ARC) in cancer.

Authors:  Zhongjie Yu; Qi Li; Yi An; Xiatian Chen; Ziqian Liu; Zhe Li; Jinning Gao; Lynn Htet Htet Aung; Peifeng Li
Journal:  Oncol Lett       Date:  2019-10-11       Impact factor: 2.967
  5 in total

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