| Literature DB >> 11535328 |
M L Pitt1, S F Little, B E Ivins, P Fellows, J Barth, J Hewetson, P Gibbs, M Dertzbaugh, A M Friedlander.
Abstract
A serological correlate of vaccine-induced immunity was identified in the rabbit model of inhalational anthrax. Animals were inoculated intramuscularly at 0 and 4 weeks with varying doses of Anthrax Vaccine Adsorbed (AVA) ranging from a human dose to a 1:256 dilution in phosphate-buffered saline (PBS). At 6 and 10 weeks, both the quantitative anti-protective antigen (PA) IgG ELISA and the toxin-neutralizing antibody (TNA) assays were used to measure antibody levels to PA. Rabbits were aerosol-challenged at 10 weeks with a lethal dose (84-133 LD(50)) of Bacillus anthracis spores. All the rabbits that received the undiluted and 1:4 dilution of vaccine survived, whereas those receiving the higher dilutions of vaccine (1:16, 1:64 and 1:256) had deaths in their groups. Results showed that antibody levels to PA at both 6 and 10 weeks were significant (P<0.0001) predictors of survival.Entities:
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Year: 2001 PMID： 11535328 DOI： 10.1016/s0264-410x(01)00234-1
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641