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Literature DB >> 11533661

UDP-sugar transporter implicated in glycosylation and processing of Notch.

S Goto¹, M Taniguchi, M Muraoka, H Toyoda, Y Sado, M Kawakita, S Hayashi.

Abstract

Glycosylation modifies protein activities in various biological processes. Here, we report the functions of a novel UDP-sugar transporter (UST74C, an alternative name for Fringe connection (Frc)) localized to the Golgi apparatus in cellular signalling of Drosophila. Mutants in the frc gene exhibit phenotypes resembling wingless and Notch mutants. Both Fringe-dependent and Fringe-independent Notch pathways are affected, and both glycosylation and proteolytic maturation of Notch are defective in mutant larvae. The results suggest that changes in nucleotide-sugar levels can differently affect Wingless and two distinct aspects of Notch signalling.

Entities: Chemical Gene Species

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Year: 2001 PMID： 11533661 DOI： 10.1038/ncb0901-816

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

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Cited

35 in total

1. Development and characterization of new cell line BPH22 from midgut epithelial cells of Poekilocerus pictus (Fabricius, 1775).

Authors: Kiran R Kharat; Madhavi V Sawant; Shiney Peter; Bhagyashree P Hardikar
Journal: In Vitro Cell Dev Biol Anim Date: 2010-10-07 Impact factor: 2.416

2. Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.

Authors: Florian Lüders; Hiroaki Segawa; David Stein; Erica M Selva; Norbert Perrimon; Salvatore J Turco; Udo Häcker
Journal: EMBO J Date: 2003-07-15 Impact factor: 11.598

Review 3. Role of glycans and glycosyltransferases in the regulation of Notch signaling.

Authors: Hamed Jafar-Nejad; Jessica Leonardi; Rodrigo Fernandez-Valdivia
Journal: Glycobiology Date: 2010-04-05 Impact factor: 4.313

4. A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation.

Authors: Bo Thomsen; Per Horn; Frank Panitz; Emøke Bendixen; Anette H Petersen; Lars-Erik Holm; Vivi H Nielsen; Jørgen S Agerholm; Jens Arnbjerg; Christian Bendixen
Journal: Genome Res Date: 2005-12-12 Impact factor: 9.043

UDP-sugar transporter implicated in glycosylation and processing of Notch.

1. Development and characterization of new cell line BPH22 from midgut epithelial cells of Poekilocerus pictus (Fabricius, 1775).

2. Slalom encodes an adenosine 3'-phosphate 5'-phosphosulfate transporter essential for development in Drosophila.

Review 3. Role of glycans and glycosyltransferases in the regulation of Notch signaling.

4. A missense mutation in the bovine SLC35A3 gene, encoding a UDP-N-acetylglucosamine transporter, causes complex vertebral malformation.

5. Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation.

6. Independent and simultaneous translocation of two substrates by a nucleotide sugar transporter.

Review 7. Integration of Drosophila and Human Genetics to Understand Notch Signaling Related Diseases.

8. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.

9. N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs.

Review 10. Glycobiology on the fly: developmental and mechanistic insights from Drosophila.