Literature DB >> 1153331

Formation of internucleotide 3'-5' phosphoramidate links by direct coupling of phosphoryl and amino groups.

G L Greene, R L Letsinger.   

Abstract

The stepwise synthesis of oligomers derived from 5'-amino-5'-deoxythymidine 3'-phosphate and 5'-amino-5'-deoxy-3'-O-mono-p-methoxytrityl-thymidine is described. The internucleotide phosphoramidate links were formed by condensation of nucleoside 3'-phosphates with aminonucleosides by means of triphenylphosphine and dipridyl disulfide.

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Year:  1975        PMID： 1153331      PMCID： PMC343499          DOI： 10.1093/nar/2.7.1123

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  5 in total

1.  Enzymatic synthesis of polydeoxyribonucleotides possessing internucleotide phosphoramidate bonds.

Authors:  R L Letsinger; J S Wilkes; L B Dumas
Journal:  J Am Chem Soc       Date:  1972-01-12       Impact factor: 15.419

2.  Use of trityl- and -naphthylcarbamoylcellulose derivatives in oligonucleotide synthesis.

Authors:  P J Cashion; M Fridkin; K L Agarwal; E Jay; H G Khorana
Journal:  Biochemistry       Date:  1973-05-08       Impact factor: 3.162

3.  Phosphoramidate analogs of oligonucleotides.

Authors:  R L Letsinger; W S Mungall
Journal:  J Org Chem       Date:  1970-11       Impact factor: 4.354

4.  Use of phosphorus oxychloride in synthesizing nucleotides and oligonucleotides.

Authors:  W S Mungall; G L Greene; P S Miller; R L Letsinger
Journal:  Nucleic Acids Res       Date:  1974-04       Impact factor: 16.971

5.  Synthesis of oligothymidylates and nucleoside cyclic phosphates by oxidation-reduction condensation.

Authors:  T Mukaiyama; M Hashimoto
Journal:  J Am Chem Soc       Date:  1972-11-29       Impact factor: 15.419
  5 in total
  1 in total

1.  Synthesis and properties of oligonucleotides containing aminodeoxythymidine units.

Authors:  S M Gryaznov; R L Letsinger
Journal:  Nucleic Acids Res       Date:  1992-07-11       Impact factor: 16.971
  1 in total

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