Literature DB >> 11533213

The Kaposi's sarcoma-associated herpesvirus K8 protein interacts with CREB-binding protein (CBP) and represses CBP-mediated transcription.

S Hwang1, Y Gwack, H Byun, C Lim, J Choe.   

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame K8 encodes a basic region-leucine zipper protein of 237 amino acids that homodimerizes with its bZIP domain. KSHV K8 shows significant homology to the Epstein-Barr virus (EBV) immediate-early protein Zta, a key regulator in the reactivation and replication of EBV. In this study, we report that K8, like its homolog EBV Zta, interacts with cellular CREB-binding protein (CBP) in vivo and in vitro. This interaction requires the C/H3 domain of CBP and the basic region of K8. K8 represses CBP-mediated transcription by competing with limited amounts of cellular CBP, exemplified by the reduced expression from the AP-1 and human immunodeficiency virus long terminal repeat promoters.

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Year:  2001        PMID： 11533213      PMCID： PMC114518          DOI： 10.1128/JVI.75.19.9509-9516.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  43 in total

1.  Association of p300 and CBP with simian virus 40 large T antigen.

Authors:  R Eckner; J W Ludlow; N L Lill; E Oldread; Z Arany; N Modjtahedi; J A DeCaprio; D M Livingston; J A Morgan
Journal:  Mol Cell Biol       Date:  1996-07       Impact factor: 4.272

2.  Synergistic activation of transcription by CBP and p53.

Authors:  W Gu; X L Shi; R G Roeder
Journal:  Nature       Date:  1997-06-19       Impact factor: 49.962

3.  Binding and modulation of p53 by p300/CBP coactivators.

Authors:  N L Lill; S R Grossman; D Ginsberg; J DeCaprio; D M Livingston
Journal:  Nature       Date:  1997-06-19       Impact factor: 49.962

4.  The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

Authors:  J C Dorsman; A F Teunisse; A Zantema; A J van der Eb
Journal:  J Gen Virol       Date:  1997-02       Impact factor: 3.891

5.  Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.

Authors:  V J LaMorte; J A Dyck; R L Ochs; R M Evans
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

6.  Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).

Authors:  J J Russo; R A Bohenzky; M C Chien; J Chen; M Yan; D Maddalena; J P Parry; D Peruzzi; I S Edelman; Y Chang; P S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

7.  Selective switch between latency and lytic replication of Kaposi's sarcoma herpesvirus and Epstein-Barr virus in dually infected body cavity lymphoma cells.

Authors:  G Miller; L Heston; E Grogan; L Gradoville; M Rigsby; R Sun; D Shedd; V M Kushnaryov; S Grossberg; Y Chang
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

8.  Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator.

Authors:  N D Perkins; L K Felzien; J C Betts; K Leung; D H Beach; G J Nabel
Journal:  Science       Date:  1997-01-24       Impact factor: 47.728

9.  CREB-binding protein/p300 are transcriptional coactivators of p65.

Authors:  M E Gerritsen; A J Williams; A S Neish; S Moore; Y Shi; T Collins
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

10.  A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors.

Authors:  Y Kamei; L Xu; T Heinzel; J Torchia; R Kurokawa; B Gloss; S C Lin; R A Heyman; D W Rose; C K Glass; M G Rosenfeld
Journal:  Cell       Date:  1996-05-03       Impact factor: 41.582
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  24 in total

1.  Role of CCAAT/enhancer-binding protein alpha (C/EBPalpha) in activation of the Kaposi's sarcoma-associated herpesvirus (KSHV) lytic-cycle replication-associated protein (RAP) promoter in cooperation with the KSHV replication and transcription activator (RTA) and RAP.

Authors:  Shizhen Emily Wang; Frederick Y Wu; Masahiro Fujimuro; Jianchao Zong; S Diane Hayward; Gary S Hayward
Journal:  J Virol       Date:  2003-01       Impact factor: 5.103

Review 2.  Molecular biology of KSHV in relation to AIDS-associated oncogenesis.

Authors:  Whitney Greene; Kurt Kuhne; Fengchun Ye; Jiguo Chen; Fuchun Zhou; Xiufen Lei; Shou-Jiang Gao
Journal:  Cancer Treat Res       Date:  2007

3.  Investigation of the multimerization region of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) protein K-bZIP: the proposed leucine zipper region encodes a multimerization domain with an unusual structure.

Authors:  Salama Al Mehairi; Eleanora Cerasoli; Alison J Sinclair
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

Review 4.  Epigenetic regulation of Kaposi's sarcoma-associated herpesvirus replication.

Authors:  Shara N Pantry; Peter G Medveczky
Journal:  Semin Cancer Biol       Date:  2009-02-21       Impact factor: 15.707

5.  A comprehensive analysis of recruitment and transactivation potential of K-Rta and K-bZIP during reactivation of Kaposi's sarcoma-associated herpesvirus.

Authors:  Thomas J Ellison; Yoshihiro Izumiya; Chie Izumiya; Paul A Luciw; Hsing-Jien Kung
Journal:  Virology       Date:  2009-03-09       Impact factor: 3.616

Review 6.  Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.

Authors:  Qiliang Cai; Suhbash C Verma; Jie Lu; Erle S Robertson
Journal:  Adv Virus Res       Date:  2010       Impact factor: 9.937

7.  Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification.

Authors:  Yoshihiro Izumiya; Thomas J Ellison; Edward T H Yeh; Jae U Jung; Paul A Luciw; Hsing-Jien Kung
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

8.  The replication and transcription activator of murine gammaherpesvirus 68 cooperatively enhances cytokine-activated, STAT3-mediated gene expression.

Authors:  Hui-Chen Chang Foreman; Julie Armstrong; Alexis L Santana; Laurie T Krug; Nancy C Reich
Journal:  J Biol Chem       Date:  2017-08-15       Impact factor: 5.157

Review 9.  Viral manipulation of the host epigenome for oncogenic transformation.

Authors:  Roberto Ferrari; Arnold J Berk; Siavash K Kurdistani
Journal:  Nat Rev Genet       Date:  2009-05       Impact factor: 53.242

10.  Cell cycle regulation by Kaposi's sarcoma-associated herpesvirus K-bZIP: direct interaction with cyclin-CDK2 and induction of G1 growth arrest.

Authors:  Yoshihiro Izumiya; Su-Fang Lin; Thomas J Ellison; Alon M Levy; Greg L Mayeur; Chie Izumiya; Hsing-Jien Kung
Journal:  J Virol       Date:  2003-09       Impact factor: 5.103
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